Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-induced Senescence

Autor: Elizabeth P. Crowe, Ferit Tuzer, Brian D. Gregory, Greg Donahue, Sager J. Gosai, Justin Cohen, Yuk Yee Leung, Emre Yetkin, Raffaella Nativio, Li-San Wang, Christian Sell, Nancy M. Bonini, Shelley L. Berger, F Brad Johnson, Claudio Torres

Publikováno v: Frontiers in Aging Neuroscience, Vol 8 (2016)

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression,

Externí odkaz: https://doaj.org/article/3ae31c0b3bc84fef8025ad4be73ee323

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH

Autor: Jacob C. Ulirsch, Masahiro Kanai, Alan Gutierrez, Steven K. Reilly, Kousuke Mouri, Daniel Berenzy, Susan Kales, Ryan Tewhey, Ava Mackay-Smith, Pardis C. Sabeti, Redwan M Bhuiyan, Sager J. Gosai, Michael L. Stitzel, Hilary K. Finucane, Adrianne Gladden-Young, Gina M Butler

Publikováno v: Nat Genet

Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed hybridization chain reaction fluorescence in situ hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bf57d83bf66d5852c902c570cd6737
https://doi.org/10.1038/s41588-021-00900-4

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

Autor: Alexandre Amlie-Wolf, Amit Berson, Sager J. Gosai, F. Brad Johnson, Yemin Lan, Jon B. Toledo, Greg Donahue, Nancy M. Bonini, Ferit Tuzer, Claudio Torres, John Q. Trojanowski, Li-San Wang, Shelley L. Berger, Raffaella Nativio, Brian D. Gregory

Publikováno v: Nature Neuroscience. 21:497-505

Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339124c304f57be19a3aae365dbca80b
https://doi.org/10.1038/s41593-018-0101-9

Global analysis of ribosome-associated noncoding RNAs unveils new modes of translational regulation

Autor: Katja Baerenfaller, Martin Crespi, Julia Bailey-Serres, Jérémie Bazin, Brian D. Gregory, Sager J. Gosai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩
Proceedings of the National Academy of Sciences of the United States of America, 114 (46)
Proceedings of the National Academy of Sciences of the United States of America 46 (114), E10018-E10027. (2017)
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩

Eukaryotic transcriptomes contain a major non–protein-coding component that includes precursors of small RNAs as well as long noncoding RNA (lncRNAs). Here, we utilized the mapping of ribosome footprints on RNAs to explore translational regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968841e1022b10a3013227ff807c53c7
http://europepmc.org/articles/PMC5699049

Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism

Autor: Chenyi Xue, Benjamin A. Garcia, Wen Liu, Wenjun Li, Xuan Zhang, Melanie Hachet, Yumiao Han, John B. Hogenesch, Muredach P. Reilly, Patrick Seale, Jennie Lin, Sager J. Gosai, Jane F. Ferguson, Amber K. Weiner, Brian D. Gregory, Raymond E. Soccio, Mingyao Li, Hongfeng Jiang, Christine C. Hinkle

Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9eb738f9a7c3cafd946c68cea91b6f7
https://europepmc.org/articles/PMC6620026/