Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sager J Gosai"'
Autor:
Sager J Gosai, Joon Hyeok Kwak, Cliff J Luke, Olivia S Long, Dale E King, Kevin J Kovatch, Paul A Johnston, Tong Ying Shun, John S Lazo, David H Perlmutter, Gary A Silverman, Stephen C Pak
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15460 (2010)
The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, howe
Externí odkaz:
https://doaj.org/article/84a23b8725da453282e732e846ecd8d0
Autor:
Jacob C. Ulirsch, Masahiro Kanai, Alan Gutierrez, Steven K. Reilly, Kousuke Mouri, Daniel Berenzy, Susan Kales, Ryan Tewhey, Ava Mackay-Smith, Pardis C. Sabeti, Redwan M Bhuiyan, Sager J. Gosai, Michael L. Stitzel, Hilary K. Finucane, Adrianne Gladden-Young, Gina M Butler
Publikováno v:
Nat Genet
Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed hybridization chain reaction fluorescence in situ hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bf57d83bf66d5852c902c570cd6737
https://doi.org/10.1038/s41588-021-00900-4
https://doi.org/10.1038/s41588-021-00900-4
Autor:
Susan Kales, Pardis C. Sabeti, Jacob C. Ulirsch, Hilary K. Finucane, Austin J. Gutierrez, Masahiro Kanai, Sager J. Gosai, Ryan Tewhey, Daniel Berenzy, Steven K. Reilly, Gina M Butler, Adrianne Gladden-Young
CRISPR screens for cis-regulatory elements (CREs) have shown unprecedented power to endogenously characterize the non-coding genome. To characterize CREs we developed HCR-FlowFISH (Hybridization Chain Reaction Fluorescent In-Situ Hybridization couple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3081acd15c041de2eedf6a6cfda72c
https://doi.org/10.1101/2020.05.11.078675
https://doi.org/10.1101/2020.05.11.078675
Autor:
Alexandre Amlie-Wolf, Amit Berson, Sager J. Gosai, F. Brad Johnson, Yemin Lan, Jon B. Toledo, Greg Donahue, Nancy M. Bonini, Ferit Tuzer, Claudio Torres, John Q. Trojanowski, Li-San Wang, Shelley L. Berger, Raffaella Nativio, Brian D. Gregory
Publikováno v:
Nature Neuroscience. 21:497-505
Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339124c304f57be19a3aae365dbca80b
https://doi.org/10.1038/s41593-018-0101-9
https://doi.org/10.1038/s41593-018-0101-9
Autor:
Gina M Butler, Steven K. Reilly, Kousuke Mouri, Michael L. Stitzel, Ryan Tewhey, Redwan M Bhuiyan, Masahiro Kanai, Pardis C. Sabeti, Alan Gutierrez, Susan Kales, Sager J. Gosai, Adrianne Gladden-Young, Ava Mackay-Smith, Jacob C. Ulirsch, Hilary K. Finucane, Daniel Berenzy
Publikováno v:
Nature Genetics. 53:1517-1517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56fcf89063396a4736c8d11dd15aebee
https://doi.org/10.1038/s41588-021-00943-7
https://doi.org/10.1038/s41588-021-00943-7
Autor:
Katja Baerenfaller, Martin Crespi, Julia Bailey-Serres, Jérémie Bazin, Brian D. Gregory, Sager J. Gosai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩
Proceedings of the National Academy of Sciences of the United States of America, 114 (46)
Proceedings of the National Academy of Sciences of the United States of America 46 (114), E10018-E10027. (2017)
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩
Proceedings of the National Academy of Sciences of the United States of America, 114 (46)
Proceedings of the National Academy of Sciences of the United States of America 46 (114), E10018-E10027. (2017)
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (46), pp.E10018-E10027. ⟨10.1073/pnas.1708433114⟩
Eukaryotic transcriptomes contain a major non–protein-coding component that includes precursors of small RNAs as well as long noncoding RNA (lncRNAs). Here, we utilized the mapping of ribosome footprints on RNAs to explore translational regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968841e1022b10a3013227ff807c53c7
http://europepmc.org/articles/PMC5699049
http://europepmc.org/articles/PMC5699049
Autor:
Shankara Anand, François Aguet, Sager J. Gosai, Kristin Ardlie, Gad Getz, Eliezer M. Van Allen, Jaegil Kim, Amaro Taylor-Weiner, Nicholas J. Haradhvala
Publikováno v:
Genome Biology
Genome Biology, Vol 20, Iss 1, Pp 1-5 (2019)
Genome Biology, Vol 20, Iss 1, Pp 1-5 (2019)
Current genomics methods and pipelines were designed to handle tens to thousands of samples, but will soon need to scale to millions to keep up with the pace of data and hypothesis generation in biomedical science. The computational costs associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2467334bf7dfede89909e9c5fe693f83
Autor:
Chenyi Xue, Benjamin A. Garcia, Wen Liu, Wenjun Li, Xuan Zhang, Melanie Hachet, Yumiao Han, John B. Hogenesch, Muredach P. Reilly, Patrick Seale, Jennie Lin, Sager J. Gosai, Jane F. Ferguson, Amber K. Weiner, Brian D. Gregory, Raymond E. Soccio, Mingyao Li, Hongfeng Jiang, Christine C. Hinkle
Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9eb738f9a7c3cafd946c68cea91b6f7
https://europepmc.org/articles/PMC6620026/
https://europepmc.org/articles/PMC6620026/
Autor:
Nathan D. Berkowitz, Shawn W. Foley, Zissimos Mourelatos, Sager J. Gosai, Nicholas Vrettos, Ian M. Silverman, Brian D. Gregory
MicroRNA precursors (pre-miRNAs) are short hairpin RNAs that are rapidly processed into mature microRNAs (miRNAs) in the cytoplasm. Due to their low abundance in cells, sequencing-based studies of pre-miRNAs have been limited. We successfully enriche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dffa460a434422df45914210ca8c315
Autor:
Hanrui Zhang, Edward E. Morrisey, Sager J. Gosai, Kate Bermingham, Christine C. Hinkle, Muredach P. Reilly, Evanthia E. Pashos, Marina Cuchel, Wenjun Li, John S. Millar, Ruilan Yan, Stella T. Chou, Ying Liu, Jennifer Tabita-Martinez, Chenyi Xue, Amrith Rodrigues, Wenli Yang, Daniel J. Rader, Daniel VanDorn, Rhia Shah, Mingyao Li, Brian D. Gregory
Publikováno v:
Circulation Research. 117:17-28
Rationale: An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases. Objective: To perform integrated functional and transcriptome analyses of human induced pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc90169da44c924681263b248a1987
https://doi.org/10.1161/circresaha.117.305860
https://doi.org/10.1161/circresaha.117.305860