Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex

Autor: Sagar Sridhara, Jay Rai, Charlisa Whyms, Hemant Goswami, Huan He, Walter Woodside, Michael P. Terns, Hong Li

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

This study presents Cryo-EM structures of the Lactococcus lactis Type III-A CRISPR-Cas effector complex in three functional states, including bound forms with cognate and non-cognate target RNA. The results suggest changing protein dynamics during ef

Externí odkaz: https://doaj.org/article/4b9b4f8dde8c45529486ef3987f03a7c

Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases.

Autor: Kunvariya AD; Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India., Dave SA; Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India., Modi ZJ; Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India., Patel PK; Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India., Sagar SR; Department of Pharmaceutical Chemistry, L.J. Institute of Pharmacy, L J University, Ahmedabad 382 210, India.

Publikováno v: Heliyon [Heliyon] 2023 Apr 20; Vol. 9 (5), pp. e15644. Date of Electronic Publication: 2023 Apr 20 (Print Publication: 2023).

Insights into the structural requirements of triazole derivatives as promising DPP IV inhibitors: computational investigations.

Autor: Shah BM; Department of Pharmaceutical Chemistry, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.; Department of Pharmaceutical Chemistry, L. J. Institute of Pharmacy, L. J. University, Ahmedabad, Gujarat, India., Sagar SR; Department of Pharmaceutical Chemistry, L. J. Institute of Pharmacy, L. J. University, Ahmedabad, Gujarat, India., Trivedi P; Department of Pharmaceutical Chemistry, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2022; Vol. 40 (24), pp. 13778-13798. Date of Electronic Publication: 2021 Nov 05.

In silico studies on therapeutic agents for COVID-19: Drug repurposing approach.

Autor: Shah B; L. J. Institute of Pharmacy, S. G. Highway, Sanand Circle, Sarkhej, Ahmedabad, Gujarat 382210, India; Registered Research Scholar K B Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat 382023, India. Electronic address: bhumi.shah_ljip@ljinstitutes.edu.in., Modi P; L. J. Institute of Pharmacy, S. G. Highway, Sanand Circle, Sarkhej, Ahmedabad, Gujarat 382210, India., Sagar SR; L. J. Institute of Pharmacy, S. G. Highway, Sanand Circle, Sarkhej, Ahmedabad, Gujarat 382210, India.

Publikováno v: Life sciences [Life Sci] 2020 Jul 01; Vol. 252, pp. 117652. Date of Electronic Publication: 2020 Apr 09.

Thiazolyl-thiadiazines as Beta Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1) Inhibitors and Anti-inflammatory Agents: Multitarget-Directed Ligands for the Efficient Management of Alzheimer's Disease.

Autor: Sagar SR; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India.; Institute of Pharmacy , NIRMA University , S. G. Highway , Chandlodia, Gota, Ahmedabad , 382481 Gujarat , India., Singh DP; Department of Pharmacology and Toxicology , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India., Panchal NB; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India.; Institute of Pharmacy , NIRMA University , S. G. Highway , Chandlodia, Gota, Ahmedabad , 382481 Gujarat , India., Das RD; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India., Pandya DH; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India., Sudarsanam V; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India., Nivsarkar M; Department of Pharmacology and Toxicology , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India., Vasu KK; Department of Medicinal Chemistry , B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway , Thaltej, Ahmedabad , 380054 Gujarat , India.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2018 Jul 18; Vol. 9 (7), pp. 1663-1679. Date of Electronic Publication: 2018 May 10.