Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sagar S. Varankar"'
Publikováno v:
Computational and Systems Oncology, Vol 2, Iss 3, Pp n/a-n/a (2022)
Abstract In vitro migration assays are a cornerstone of cell biology and have found extensive utility in research. Over the past decade, several variations of the two‐dimensional (2D) migration assay have improved our understanding of this fundamen
Externí odkaz:
https://doaj.org/article/54fed7aa22fa465dba1e488edd2d8c38
Autor:
Rajkumar S. Kalra, Gaurav S. Soman, Pradeep B. Parab, Avinash M. Mali, Sagar S. Varankar, Rutika R. Naik, Swapnil C. Kamble, Jaspreet K. Dhanjal, Sharmila A. Bapat
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101257- (2022)
The involvement of cancer stem cells (CSCs) in driving tumor dormancy and drug resistance is well established. Most therapeutic regimens however are ineffective in targeting these regenerative populations. We report the development and evaluation of
Externí odkaz:
https://doaj.org/article/91d3788dfffb4d0796bea9dfa401f8ee
Autor:
Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis
Publikováno v:
Nature. 615:134-142
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t
Autor:
Sagar S. Varankar, Sharmila A. Bapat
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Metastatic dissemination generates an aggressive disease facilitated by enhanced migratory and invasive properties. Experimental approaches employ several in vitro and in vivo assays toward quantification of these functionalities. In vitro assessment
Externí odkaz:
https://doaj.org/article/70d90b9bacec4a7fabdb3c838a41f430
Ex situ experimental models have become a main stay in pulmonary research. Organoids and explant systems have uncovered novel stem cell subsets, served as disease models, delineated cell fate transitions, and aided high throughput pre-clinical drug s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03710c90b7e8926d5d648d446d1b5099
Autor:
Sagar S. Varankar, Sharmila A. Bapat
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 7, p 941 (2019)
The experimental evaluation of metastasis overly focuses on the gain of migratory and invasive properties, while disregarding the contributions of cellular plasticity, extra-cellular matrix heterogeneity, niche interactions, and tissue architecture.
Externí odkaz:
https://doaj.org/article/ad900a1320e44e0aa6827d9a2b6597fb
Autor:
Madhuri H. More, Sagar S. Varankar, Rutika R. Naik, Rahul D. Dhake, Pritha Ray, Rahul M. Bankar, Avinash M. Mali, Ayalur Raghu Subbalakshmi, Priyanka Chakraborty, Mohit Kumar Jolly, Sharmila A. Bapat
Publikováno v:
Cells, tissues, organs.
High-grade serous ovarian carcinoma (HGSC) is associated with late-stage disease presentation and poor prognosis, with limited understanding of early transformation events. Our study presents a comprehensive analysis of tumor progression and organ-sp
BackgroundIn vitromigration assays are a cornerstone of cell biology and have found extensive utility in research. Over the past decade, several variations of the two-dimensional (2D) migration assay have improved our understanding of this fundamenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f47a668e0d5eb8b9a9f82d408ef0b22
https://doi.org/10.1101/2021.12.22.473305
https://doi.org/10.1101/2021.12.22.473305
Autor:
Pradeep B. Parab, Sagar S. Varankar, Jaspreet Kaur Dhanjal, Rutika. R. Naik, Sharmila A. Bapat, Rajkumar S. Kalra, Swapnil C. Kamble, Avinash M. Mali, Gaurav S. Soman
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101257-(2022)
Translational Oncology
Translational Oncology
Highlights • Development of a novel antibody (termed as mAb150) developed in our lab which targets annexin A2. • Although there are earlier reports of another monoclonal antibody with the same target, the epitope recognized by mAb150 is novel.
Autor:
Madhuri More, Kshama Pansare, Ancy Abraham, Brijesh Kumar, Mohit Kumar Jolly, Sagar S. Varankar, Avinash M. Mali, Sharmila A. Bapat, Nivedhitha J Narayanan
Publikováno v:
Carcinogenesis. 41:515-526
Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to mesenchymal transition (EMT) or cooperative cell migration (CCM). Our study identifies novel regulatory cross-