Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sagar S Damle"'
Autor:
Lulu Huang, Sagar S Damle, Sheri Booten, Priyam Singh, Mahyar Sabripour, Jeff Hsu, Minji Jo, Melanie Katz, Andy Watt, Christopher E Hart, Susan M Freier, Brett P Monia, Shuling Guo
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132798 (2015)
Liver regeneration after partial hepatectomy (PHx) is a complex and well-orchestrated biological process in which synchronized cell proliferation is induced in response to the loss of liver mass. To define long noncoding RNAs (lncRNAs) that participa
Externí odkaz:
https://doaj.org/article/6cb40089f7c54364ba90740f1b4158a0
Autor:
Christine E. Cho, Sagar S. Damle, Edward V. Wancewicz, Swagatam Mukhopadhyay, Christopher E. Hart, Curt Mazur, Eric E. Swayze, Fredrik Kamme
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the role microglia play in neurodegeneration, CNS injury, and developm
Externí odkaz:
https://doaj.org/article/93988ddf97354f41be11fd97dfc4427b
Autor:
Lulu Huang, Audrey Low, Sagar S. Damle, Melissa M. Keenan, Steven Kuntz, Susan F. Murray, Brett P. Monia, Shuling Guo
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also
Externí odkaz:
https://doaj.org/article/8ab099ebcff244beb8bcc89c1831c531
Autor:
Steven Kuntz, Brett P. Monia, Sagar S. Damle, Jeff Crosby, Guizhen Sun, Tamar R. Grossman, Christopher E. Hart, Michele Carrer, Chenguang Zhao
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:46-56
Goblet cell metaplasia, excessive mucus production, and inadequate mucus clearance accompany and exacerbate multiple chronic respiratory disorders, such as asthma and chronic obstructive pulmonary disease. Notch signaling plays a central role in cont
Autor:
Paola Delbini, Maxwell Chappell, Valentina Ghiaccio, Danuta Jarocha, Coralea Stephanou, Maria Domenica Cappellini, Marina Kleanthous, Soteroula Christou, Shuling Guo, Kim Smith-Whitley, Irene Motta, Carla Casu, Alisa Dong, Deepa Manwani, Connie Chen, Susan M. Freier, Stefano Rivella, Andrew T. Watt, Laura Breda, Yasuhiro Ikawa, Raechel Peralta, Osheiza Abdulmalik, Sagar S. Damle
Publikováno v:
Haematologica
β-thalassemia is a disorder caused by altered hemoglobin protein synthesis and affects individuals worldwide. Severe forms of the disease, left untreated, can result in death before the age of 3 years (1). The standard of care consists of chronic an
Autor:
Holly Kordasiewicz, Hien T Zhao, Jian Li, Apoorva Mohan, Steven Kuntz, Aneeza Kim, John Svaren, Mark A. Scheideler, Eric E. Swayze, Sagar S. Damle, Gene Hung, Karli Ikeda-Lee, Steven S. Scherer
Publikováno v:
Journal of Clinical Investigation. 128:359-368
Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by duplication of peripheral myelin protein 22 (PMP22) and is the most common hereditary peripheral neuropathy. CMT1A is characterized by demyelination and axonal loss, which underlie slowed motor
Autor:
Sagar S. Damle, Stanley T. Crooke, Rosanne M. Crooke, Wen Shen, Michael T. Migawa, Huynh-Hoa Bui, Xue-hai Liang, Stan Riney, Mark J. Graham, Shiyu Wang, Joyee Yao, Hong Sun
Publikováno v:
Nucleic Acids Research
A variety of diseases are caused by deficiencies in amounts or activity of key proteins. An approach that increases the amount of a specific protein might be of therapeutic benefit. We reasoned that translation could be specifically enhanced using tr
Autor:
Edward Wancewicz, Eric E. Swayze, Fredrik Kamme, Curt Mazur, Sagar S. Damle, Christopher E. Hart, Swagatam Mukhopadhyay, Christine E. Cho
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-16 (2019)
BMC Genomics
BMC Genomics
Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the role microglia play in neurodegeneration, CNS injury, and developmental dis
Autor:
Michael J. Weyant, Sagar S. Damle, John D. Mitchell, Nathaen Weitzel, Andrew K. Sullivan, Teresa S. Jones, Robert A. Meguid
Publikováno v:
Seminars in Cardiothoracic and Vascular Anesthesia. 21:99-104
Tracheal laceration is a known complication of endotracheal intubation. This rare complication remains a diagnostic and management challenge for today’s practitioners. This clinical challenge report highlights current surgical and anesthetic manage
Publikováno v:
Molecular Cell. 77:1032-1043.e4
An attractive approach to reduce gene expression is via the use of antisense oligonucleotides (ASOs) that harness the RNase H1 mechanism. Here we show that RNase H ASOs targeted to introns or exons robustly reduce the level of spliced RNA associated