Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sagar Kathuria"'
Autor:
Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into w
Externí odkaz:
https://doaj.org/article/08adf8bbba7940a8b4cc3c5378c32316
Autor:
Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero, Lindsay Avery
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
In vitro assessments for the prediction of pharmacokinetic (PK) behavior of biotherapeutics can help identify corresponding liabilities significantly earlier in the discovery timeline. This can minimize the need for extensive early in vivo PK charact
Externí odkaz:
https://doaj.org/article/38817983990a4fd685f565a20d0c4cd1
Autor:
Andrew M Stern, Lei Liu, Shanxue Jin, Wen Liu, Angela L Meunier, Maria Ericsson, Michael B Miller, Megan Batson, Tingwan Sun, Sagar Kathuria, David Reczek, Laurent Pradier, Dennis J Selkoe
Publikováno v:
Brain : a journal of neurology. 145(7)
Aqueously soluble oligomers of amyloid-β peptide may be the principal neurotoxic forms of amyloid-β in Alzheimer’s disease, initiating downstream events that include tau hyperphosphorylation, neuritic/synaptic injury, microgliosis and neuron loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37befc246416cd0360b7a28063891ef
https://pubmed.ncbi.nlm.nih.gov/35084489
https://pubmed.ncbi.nlm.nih.gov/35084489
Autor:
Tristan Magnay, Anusuya Ramasubramanian, Dietmar Hoffmann, Pierrick Rival, Maureen Magnay, Rachel Tennyson, Megan Salemi, Dana M. Lord, Annu Jain, Eva Bric-Furlong, Jiali Hu, Katarina Radošević, William Brondyk, Caitlin Sullivan, Yanfeng Zhou, Tara Travaline, Sagar Kathuria, Partha S. Chowdhury
Publikováno v:
Antibodies
Volume 9
Issue 4
Volume 9
Issue 4
Bispecific molecules are biologically significant, yet their complex structures pose important manufacturing and pharmacokinetic challenges. Nevertheless, owing to similarities with monoclonal antibodies (mAbs), IgG-like bispecifics conceptually alig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9118f93900d71a8df72d9d93e5e0305