Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sagar, Utturkar"'
Autor:
Zhili Li, Woojun Kim, Sagar Utturkar, Bingyu Yan, Nadia Atallah Lanman, Bennett D. Elzey, Majid Kazemian, Yoon Yeo, Ourania Andrisani
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-14 (2024)
Abstract In advanced hepatocellular carcinoma (HCC), RNA helicase DDX5 regulates the Wnt/β-catenin-ferroptosis axis, influencing the efficacy of the multi-tyrosine kinase inhibitor (mTKI) sorafenib. DDX5 inhibits Wnt/β-catenin signaling, preventing
Externí odkaz:
https://doaj.org/article/30314fb41df041168377fa1afba66aba
Publikováno v:
Cell Insight, Vol 3, Iss 5, Pp 100184- (2024)
The present study focused on comparing the gene expression profiles of different mouse models of prostate cancer, focusing on the TRAMP transgenic model and its derived cell lines and extending the comparisons to relevant genetically engineered mouse
Externí odkaz:
https://doaj.org/article/adead4b57e40432fa80a220a05b97d3b
Autor:
Kyle B. Lupo, Xue Yao, Shambhavi Borde, Jiao Wang, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, MacKenzie McIntosh, Sandro Matosevic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Severe heterogeneity within glioblastoma has spurred the notion that disrupting the interplay between multiple elements on immunosuppression is at the core of meaningful anti-tumor responses. T cell immunoreceptor with Ig and ITIM domains (T
Externí odkaz:
https://doaj.org/article/1e2e1119049944b2a09484ad5864089e
Autor:
Zhili Li, Claude Caron de Fromentel, Woojun Kim, Wen-Hung Wang, Jiazeng Sun, Bingyu Yan, Sagar Utturkar, Nadia Atallah Lanman, Bennett D. Elzey, Yoon Yeo, Hao Zhang, Majid Kazemian, Massimo Levrero, Ourania Andrisani
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-14 (2023)
Abstract Reduced expression of the RNA helicase DDX5 associated with increased hepatocellular carcinoma (HCC) tumor grade and poor patient survival following treatment with sorafenib. While immunotherapy is the first-line treatment for HCC, sorafenib
Externí odkaz:
https://doaj.org/article/3768119de0414d8a98fbd38fbf6f6e99
TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
Autor:
Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, MacKenzie McIntosh, Karen E. Pollok, Sandro Matosevic
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108353- (2023)
Summary: TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulat
Externí odkaz:
https://doaj.org/article/fc412162de6f40f686eec4555f885cb5
Autor:
Andrea M Chambers, Kyle B Lupo, Jiao Wang, Jingming Cao, Sagar Utturkar, Nadia Lanman, Victor Bernal-Crespo, Shadia Jalal, Sharon R Pine, Sandra Torregrosa-Allen, Bennett D Elzey, Sandro Matosevic
Publikováno v:
eLife, Vol 11 (2022)
Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5’-ectonucleotidase gene NT5E) is a recognized immunosuppressive mechanism contributing to immune evasion in solid tumors. Adenosine is not only known to contribute to
Externí odkaz:
https://doaj.org/article/97d6c81764a042458eef5e324c28f106
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/1cc15594b0c84d12b1a1c9252639891f
Autor:
Deborah W. Knapp, Deepika Dhawan, José A. Ramos-Vara, Timothy L. Ratliff, Gregory M. Cresswell, Sagar Utturkar, Breann C. Sommer, Christopher M. Fulkerson, Noah M. Hahn
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
There is a great need to improve the outlook for people facing urinary bladder cancer, especially for patients with invasive urothelial carcinoma (InvUC) which is lethal in 50% of cases. Improved outcomes for patients with InvUC could come from advan
Externí odkaz:
https://doaj.org/article/0206712675914fc8827da681833cf6e6
Autor:
Louie Wurch, Richard J. Giannone, Bernard S. Belisle, Carolyn Swift, Sagar Utturkar, Robert L. Hettich, Anna-Louise Reysenbach, Mircea Podar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Many microbial lineages have not yet been cultured, which hampers our understanding of their physiology. Here, Wurch et al. use single-cell genomics to infer cultivation conditions for the isolation of a tiny ectosymbiotic nanoarchaeon and its crenar
Externí odkaz:
https://doaj.org/article/cf687005086c4e228cc3dcc96885b542
Autor:
Andrea M Chambers, Kyle B Lupo, Jiao Wang, Jingming Cao, Sagar Utturkar, Nadia Lanman, Victor Bernal-Crespo, Shadia Jalal, Sharon R Pine, Sandra Torregrosa-Allen, Bennett D Elzey, Sandro Matosevic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5a8372eda94200577042a76c33f18b
https://doi.org/10.7554/elife.73699.sa2
https://doi.org/10.7554/elife.73699.sa2
