Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Sagar, Sengupta"'
1
Akademický článek
Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
Autor: Mansoor Hussain, Shabnam Saifi, Aftab Mohammed, Sagar Sengupta
Publikováno v: STAR Protocols, Vol 3, Iss 4, Pp 101710- (2022)
Summary: Mitochondrial polymerase gamma (PolγA) is the only replicative polymerase in mitochondria. To determine PolγA ubiquitylation in cells, Flag-PolγA and MITOL are overexpressed, and subsequently the immunoprecipitated Flag-PolγA is checked
Externí odkaz: https://doaj.org/article/e418c10871a844d093073a174355ec39
Zobrazit plný text záznamu
3
Akademický článek
Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?
Autor: Ekjot Kaur, Ritu Agrawal, Sagar Sengupta
Publikováno v: Frontiers in Genetics, Vol 12 (2021)
DNA damage repair response is an important biological process involved in maintaining the fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in this process have been identified. Alterations in these key prote
Externí odkaz: https://doaj.org/article/dcaf2228434d4a1b98ac510397ddc0d2
Zobrazit plný text záznamu
4
Akademický článek
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Autor: Mansoor Hussain, Aftab Mohammed, Shabnam Saifi, Aamir Khan, Ekjot Kaur, Swati Priya, Himanshi Agarwal, Sagar Sengupta
Publikováno v: PLoS Biology, Vol 19, Iss 3, p e3001139 (2021)
Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the m
Externí odkaz: https://doaj.org/article/32c52093e433441ca8c4210df0a77d29
Zobrazit plný text záznamu
6
Akademický článek
Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome
Autor: Savita Lochab, Yogendra Singh, Sagar Sengupta, Vinay Kumar Nandicoori
Publikováno v: eLife, Vol 9 (2020)
(Mtb) produces inflections in the host signaling networks to create a favorable milieu for survival. The virulent Mtb strain, Rv caused double strand breaks (DSBs), whereas the non-virulent Ra strain triggered single-stranded DNA generation. The effe
Externí odkaz: https://doaj.org/article/e614b2962d27463bb5c15239ba0375ba
Zobrazit plný text záznamu
7
Akademický článek
MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
Autor: Vivek Tripathi, Himanshi Agarwal, Swati Priya, Harish Batra, Priyanka Modi, Monica Pandey, Dhurjhoti Saha, Sathees C. Raghavan, Sagar Sengupta
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Bloom helicase is recruited to double strand breaks in an ATM dependent manner. Here the authors show that Bloom helicase is recruited to double strand breaks in an ATM and MRN dependent manner with HR and NHEJ regulated by the helicase depending on
Externí odkaz: https://doaj.org/article/c3555540331742b480d02601fab3415b
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje