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Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated BBB opening: A novel combinatorial immunotherapy regimen for gliomas.

Autor: Kim KS; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Habashy K; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Gould A; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Zhao J; Department of Systems Biology, Columbia University, New York, NY, USA.; Program for Mathematical Genomics, Department of Systems Biology.; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Najem H; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Amidei C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Saganty R; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Arrieta VA; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Dmello C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Chen L; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Zhang DY; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Castro B; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Billingham L; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Levey D; Agenus Inc., Lexington, MA, USA., Huber O; Agenus Inc., Lexington, MA, USA., Marques M; Agenus Inc., Lexington, MA, USA., Savitsky DA; Agenus Inc., Lexington, MA, USA., Morin BM; Agenus Inc., Lexington, MA, USA., Muzzio M; Life Science Group, IIT Research Institute (IITRI), Chicago, IL, USA., Canney M; CarThera, Lyon, France., Horbinski C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.; Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA., Zhang P; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Miska J; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Padney S; Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Zhang B; Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Rabadan R; Department of Systems Biology, Columbia University, New York, NY, USA.; Program for Mathematical Genomics, Department of Systems Biology.; Department of Biomedical Informatics, Columbia University, New York, NY, USA., Phillips JJ; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Butowski N; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Heimberger AB; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Hu J; Department of Cancer Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX., Stupp R; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.; Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA., Chand D; Agenus Inc., Lexington, MA, USA., Lee-Chang C; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA., Sonabend AM; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Jul 19. Date of Electronic Publication: 2024 Jul 19.