Cysteine depletion induces pancreatic tumor ferroptosis in mice.

Autor: Badgley MA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Kremer DM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Maurer HC; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.; Klinikum rechts der Isar, II, Medizinische Klinik, Technische Universität München, 81675, Munich, Germany., DelGiorno KE; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Lee HJ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Purohit V; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Sagalovskiy IR; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Ma A; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Kapilian J; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Firl CEM; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Decker AR; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Sastra SA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Palermo CF; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Andrade LR; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Sajjakulnukit P; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Zhang L; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.; Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI 48105, USA., Tolstyka ZP; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Hirschhorn T; Departments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA., Lamb C; Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Liu T; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.; Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA., Gu W; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.; Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA., Seeley ES; Department of Pathology, University of California, San Francisco, CA 94143, USA.; Salvo Therapeutics, San Francisco, CA 94117, USA., Stone E; Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA., Georgiou G; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA., Manor U; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Iuga A; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.; Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA., Wahl GM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Stockwell BR; Departments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA., Olive KP; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. kenolive@columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Apr 03; Vol. 368 (6486), pp. 85-89.

Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo .

Autor: Nabavizadeh A; Department of Biomedical Engineering, Columbia University Irving Medical Center, New York, NY 10032., Payen T; Department of Biomedical Engineering, Columbia University Irving Medical Center, New York, NY 10032., Iuga AC; Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY 10032., Sagalovskiy IR; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032., Desrouilleres D; Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY 10032., Saharkhiz N; Department of Biomedical Engineering, Columbia University Irving Medical Center, New York, NY 10032., Palermo CF; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032., Sastra SA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032., Oberstein PE; Laura and Isaac Perlmutter Cancer Center, New York University, New York, NY., Rosario V; Division of Hematology & Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032., Kluger MD; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of GI/Endocrine Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032., Schrope BA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of GI/Endocrine Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032., Chabot JA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of GI/Endocrine Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032., Olive KP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032., Konofagou EE; Department of Biomedical Engineering, Columbia University Irving Medical Center, New York, NY 10032.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032.

Publikováno v: Theranostics [Theranostics] 2020 Mar 15; Vol. 10 (10), pp. 4614-4626. Date of Electronic Publication: 2020 Mar 15 (Print Publication: 2020).