Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Safwat T. Khan"'
Autor:
Antony D. St-Jacques, Joshua M. Rodriguez, Matthew G. Eason, Scott M. Foster, Safwat T. Khan, Adam M. Damry, Natalie K. Goto, Michael C. Thompson, Roberto A. Chica
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Structural plasticity of enzymes dictates their function. Yet, our ability to rationally remodel enzyme conformational landscapes to tailor catalytic properties remains limited. Here, we report a computational procedure for tuning conformati
Externí odkaz:
https://doaj.org/article/c5dbd4d40ae840a6a59e282e97bd6c6b
The pancreatic islet vasculature displays tissue-specific physiological and functional adaptations that support rapid glucose sensing and insulin response by β-cells. To uncover the transcriptomic basis of this specialization, we performed a meta-an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::746dc6f283bad5c75e498c11496f3e70
https://doi.org/10.1101/2023.04.19.537540
https://doi.org/10.1101/2023.04.19.537540
Autor:
William L. Stanford, Caryn Y. Ito, Mitchell Sabloff, Theodore J. Perkins, F. Jeffrey Dilworth, Alexander J. Ruthenburg, Elham Sabri, Adrian T. Grzybowski, Yuefeng Li, Joel P. Howard, Safwat T. Khan, Hannah L. Battaion, Julien Yockell-Lelièvre, Christopher J. Porter, Janet L. Manias Rothberg, Christopher Cafariello, Hani Jrade, Harinad B. Maganti
Supplementary figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768a48405a5ec3f531527029e18918fb
https://doi.org/10.1158/2159-8290.22531762.v1
https://doi.org/10.1158/2159-8290.22531762.v1
Autor:
William L. Stanford, Caryn Y. Ito, Mitchell Sabloff, Theodore J. Perkins, F. Jeffrey Dilworth, Alexander J. Ruthenburg, Elham Sabri, Adrian T. Grzybowski, Yuefeng Li, Joel P. Howard, Safwat T. Khan, Hannah L. Battaion, Julien Yockell-Lelièvre, Christopher J. Porter, Janet L. Manias Rothberg, Christopher Cafariello, Hani Jrade, Harinad B. Maganti
Extended Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac72e4f80651b083344b03a2662fac9b
https://doi.org/10.1158/2159-8290.22531774
https://doi.org/10.1158/2159-8290.22531774
Autor:
William L. Stanford, Caryn Y. Ito, Mitchell Sabloff, Theodore J. Perkins, F. Jeffrey Dilworth, Alexander J. Ruthenburg, Elham Sabri, Adrian T. Grzybowski, Yuefeng Li, Joel P. Howard, Safwat T. Khan, Hannah L. Battaion, Julien Yockell-Lelièvre, Christopher J. Porter, Janet L. Manias Rothberg, Christopher Cafariello, Hani Jrade, Harinad B. Maganti
Supplementary Tables 1-2, 4-6, 9-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1033bcb83d10321319d09903e0a236f7
https://doi.org/10.1158/2159-8290.22531771
https://doi.org/10.1158/2159-8290.22531771
Autor:
William L. Stanford, Caryn Y. Ito, Mitchell Sabloff, Theodore J. Perkins, F. Jeffrey Dilworth, Alexander J. Ruthenburg, Elham Sabri, Adrian T. Grzybowski, Yuefeng Li, Joel P. Howard, Safwat T. Khan, Hannah L. Battaion, Julien Yockell-Lelièvre, Christopher J. Porter, Janet L. Manias Rothberg, Christopher Cafariello, Hani Jrade, Harinad B. Maganti
Supplementary Tables 3, 7-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1bb0f9ee0c5eb3f4e21766fecb3b18
https://doi.org/10.1158/2159-8290.22531768
https://doi.org/10.1158/2159-8290.22531768
Autor:
Antony D. St-Jacques, Joshua M. Rodriguez, Matthew G. Eason, Scott M. Foster, Safwat T. Khan, Adam M. Damry, Natalie K. Goto, Michael C. Thompson, Roberto A. Chica
Structural plasticity of enzymes dictates their function. Yet, our ability to rationally remodel enzyme conformational landscapes to tailor catalytic properties remains limited. Here, we report a computational procedure for tuning conformational land
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc851cb51fb15e02aeab27097d7f72cf
https://doi.org/10.1101/2022.09.16.508321
https://doi.org/10.1101/2022.09.16.508321
Autor:
Vera M Pieters, Saifedine T Rjaibi, Kanwaldeep Singh, Nancy T Li, Safwat T Khan, Sara S Nunes, Arianna Dal Cin, Penney M Gilbert, Alison P McGuigan
Obesity prevalence has reached pandemic proportions, leaving individuals at high risk for the development of diseases such as cancer and type 2 diabetes. In obesity, to accommodate excess lipid storage, adipocytes become hypertrophic, which is associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da761dc0c6ed213ee24aeae8a785faf
https://doi.org/10.1101/2022.02.24.481624
https://doi.org/10.1101/2022.02.24.481624
Publikováno v:
Pharmacology & Therapeutics. 231:107976
Tissue vascularization remains one of the outstanding challenges in regenerative medicine. Beyond its role in circulating oxygen and nutrients, the vasculature is critical for organ development, function and homeostasis. Importantly, effective vascul
Autor:
Hernan G. Garcia, Safwat T. Khan, Matthew G. Eason, Roberto A. Chica, Antonia T. Pandelieva, Marc M. Mayer
Publikováno v:
ACS Synth Biol
Fluorescent proteins are widely used as fusion tags to detect protein expression in vivo. To become fluorescent, these proteins must undergo chromophore maturation, a slow process with a half-time of 5 to >30 min that causes delays in real-time detec