Zobrazeno 1 - 10
of 1 308
pro vyhledávání: '"Saftig, P."'
Autor:
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined th
Externí odkaz:
https://doaj.org/article/c8e7a6b3cbd440008791292cdd23c305
Autor:
Eriselda Mino, Coral L. Hanson, Inga Naber, Anja Weissenfels, Sheona McHale, Jane Saftig, Sarah Klamroth, Peter Gelius, Karim Abu-Omar, Stephen Whiting, Kremlin Wickramasinghe, Gauden Galea, Klaus Pfeifer, Wolfgang Geidl
Publikováno v:
International Journal of Behavioral Nutrition and Physical Activity, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Physical activity referral schemes (PARS) are complex multicomponent interventions that represent a promising healthcare-based concept for physical activity (PA) promotion. This systematic review and narrative synthesis aimed to i
Externí odkaz:
https://doaj.org/article/d132b1e62a124c05941ea9b254d22d1b
Autor:
Daniele Stajano, Franco L. Lombino, Michaela Schweizer, Markus Glatzel, Paul Saftig, Kira V. Gromova, Matthias Kneussel
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 9, Pp n/a-n/a (2023)
Abstract Neurons in the central nervous system release extracellular vesicles (EVs) and exosomes in response to synaptic activity to regulate physiological processes at target neurons. The intercellular transfer of proteins, mRNAs, lipids or metaboli
Externí odkaz:
https://doaj.org/article/5b642984c66640b5b1251b30ddfd3d80
Akademický článek
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Autor:
Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidoly
Externí odkaz:
https://doaj.org/article/bf1fc4064fa54fe8be2da48d70db411d
Autor:
Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction sur
Externí odkaz:
https://doaj.org/article/8d786fd470964db7bb4c1cae17ec3150
Autor:
Ulrike Ravens-Sieberer, Janine Devine, Ann-Kathrin Napp, Anne Kaman, Lynn Saftig, Martha Gilbert, Franziska Reiß, Constanze Löffler, Anja Miriam Simon, Klaus Hurrelmann, Sabine Walper, Robert Schlack, Heike Hölling, Lothar Heinz Wieler, Michael Erhart
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
PurposeFor the past three years, the German longitudinal COPSY (COVID-19 and PSYchological Health) study has monitored changes in health-related quality of life (HRQoL) and the mental health of children and adolescents during the COVID-19 pandemic.Me
Externí odkaz:
https://doaj.org/article/5e48dd9fda594969b7aca252cc4522f9
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D. Jacobsen, Bernd Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response b
Externí odkaz:
https://doaj.org/article/f2acefb3574e4b9da6fd801ea20dcfc5
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
Autor:
Ariane Schleinitz, Lara-Alina Pöttgen, Tal Keren-Kaplan, Jing Pu, Paul Saftig, Juan S. Bonifacino, Albert Haas, Andreas Jeschke
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111969- (2023)
Summary: The transfer of endocytosed cargoes to lysosomes (LYSs) requires HOPS, a multiprotein complex that tethers late endosomes (LEs) to LYSs before fusion. Many proteins interact with HOPS on LEs/LYSs. However, it is not clear whether these HOPS
Externí odkaz:
https://doaj.org/article/e4be13848ad041cbb5e8397c89a65ade