Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Safina Gadeock"'
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-8 (2022)
Abstract Objective Human intestinal organoids (hIOs) have potential as a model for investigating intestinal diseases. The hIO system faces logistic challenges including limited access to biopsies or low expression of epithelial cell types. Previous r
Externí odkaz:
https://doaj.org/article/a26493641dbb4c87aa95e26901b2b9b5
Autor:
Michael A. Schumacher, Jonathan J. Hsieh, Cambrian Y. Liu, Keren L. Appel, Amanda Waddell, Dana Almohazey, Kay Katada, Jessica K. Bernard, Edie B. Bucar, Safina Gadeock, Kathryn M. Maselli, M. Kay Washington, Tracy C. Grikscheit, David Warburton, Michael J. Rosen, Mark R. Frey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dynamic regulation of colonic secretory cell numbers is a critical component of the response to intestinal injury and inflammation. Here, the authors show that loss of the intracellular signalling regulator Sprouty2 in the intestinal epithelial cells
Externí odkaz:
https://doaj.org/article/52880ff6d53e4e2d9bd21438503b7553
Autor:
Hamish CK Angus, Paulo CM Urbano, Gemma A Laws, Shijun Fan, Safina Gadeock, Michael Schultz, Grant Butt, Andrew J Highton, Roslyn A Kemp
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Objectives Crohn's disease (CD) initiation and pathogenesis are believed to involve an environmental trigger in a genetically susceptible person that results in an immune response against commensal gut bacteria, leading to a compromised inte
Externí odkaz:
https://doaj.org/article/50612b2adcad499cb4b121421df98e85
Autor:
Edie B Bucar, Jonathan J. Hsieh, Amanda Waddell, Mark R. Frey, Kathryn M. Maselli, Safina Gadeock, Michael A. Schumacher, Jessica K. Bernard, Dana Almohazey, Kay Katada, Michael J. Rosen, M. Kay Washington, Cambrian Y. Liu, Keren Appel, David Warburton, Tracy C. Grikscheit
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the response to injury or inflammation. Sprouty2, an intracellular signaling regulator, controls pathways including PI3K and MAPKs that are implicated in differ
Publikováno v:
Gastroenterology. 160:S10-S11
Publikováno v:
Inflammatory Bowel Diseases. 27:S7-S8
Tumor necrosis factor (TNF) is a highly expressed cytokine in inflammatory bowel disease (IBD). Although TNF can induce colonic epithelial dysfunction and apoptosis, recent studies suggest that TNF signalling promotes epithelial wound repair and stem
Publikováno v:
Gastroenterology. 160:S-165
Publikováno v:
Gastroenterology. 158:S-137
Publikováno v:
Gastroenterology. 158:S-187
Autor:
Jimmy N.S.N. Tran, Jennifer G. Georgiou, Iman Jalilian, Rosanne M. Taylor, James S. Wiley, Safina Gadeock, Ronald Sluyter
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798:2058-2066
The P2X7 receptor is an extracellular ATP-gated cation channel critical in inflammation and immunity, and can be up-regulated by IFN-γ and LPS. This study aimed to examine the effect of TGF-β1 on the up-regulation of P2X7 function and expression in