Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Safiah Olabi"'
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via receptors such as integ
Externí odkaz:
https://doaj.org/article/24227d8bdb3d4c1f968b72bfafc74635
Autor:
Nan Yang, Jack Williams, Vanja Pekovic-Vaughan, Pengbo Wang, Safiah Olabi, James McConnell, Nicole Gossan, Alun Hughes, Julia Cheung, Charles H. Streuli, Qing-Jun Meng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matri
Externí odkaz:
https://doaj.org/article/955c28cf7ce343ed863b7a61fa3f8152
Autor:
Monther Al-Alwan, Safiah Olabi, Hazem Ghebeh, Eman Barhoush, Asma Tulbah, Taher Al-Tweigeri, Dahish Ajarim, Chaker Adra
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27339 (2011)
The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells. However, many studies have reported the induction of this protein in various transformed cells including br
Externí odkaz:
https://doaj.org/article/db6063dfabfd4160b6734f1e900dc24e
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Olabi, S, Ucar, A, Brennan, K & Streuli, C H 2018, ' Integrin-Rac signalling for mammary epithelial stem cell self-renewal ', Breast Cancer Research, vol. 20, no. 1 . https://doi.org/10.1186/s13058-018-1048-1
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Olabi, S, Ucar, A, Brennan, K & Streuli, C H 2018, ' Integrin-Rac signalling for mammary epithelial stem cell self-renewal ', Breast Cancer Research, vol. 20, no. 1 . https://doi.org/10.1186/s13058-018-1048-1
Background Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via receptors such as integrins. Ext
Figure S1. Tamoxifen treatment does not affect cellular distribution or organoid formation. a 4-OHT did not affect the frequency of basal or luminal progenitor cells. Primary MECs from WT mice were cultured at a density of 5 × 104 cells/well with or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40027684af2779b9bed99f99f1998191
Figure S2. Mammospheres of CD49f-, EpCAM- and CD49b-expressing cells. Before plating, the cells were selected by FACS analysis for those expressing CD49f, EpCAM and CD49b. Representative images of organoids are shown for cells with high or low levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d56390b6f99100e9c3a323ccd70a8e
Autor:
Amber Wood, Ahmet Ucar, Paulina Moreno-Layseca, Heyuan Sun, Charles H. Streuli, Safiah Olabi, Keith Brennan, Andrew P. Gilmore
Publikováno v:
Moreno Layseca, P, Ucar, A, Sun, H, Wood, A, Olabi, S, Gilmore, A, Brennan, K & Streuli, C 2017, ' The requirement of integrins for breast epithelial proliferation ', European journal of cell biology . https://doi.org/10.1016/j.ejcb.2017.03.005
Epithelial cells forming mammary gland ducts and alveoli require adhesion to the extracellular matrix for their function. Mammary epithelial cells need β1-integrins for normal cell cycle regulation. However, the role of β1-integrins in tumorigenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e7569c4164d9f1372ef6133a50a75b
https://pure.manchester.ac.uk/ws/files/53524759/53524727.EJCB_2016_182_Revision_1_V01.pdf
https://pure.manchester.ac.uk/ws/files/53524759/53524727.EJCB_2016_182_Revision_1_V01.pdf
Figure S3. Nuclear translocation of β-catenin in response to Wnt3a and GSK3i. Immunoblotting shows nuclear fractions of control and integrin-depleted cells after cells were treated with Wnt3a or GSK3i with antibodies to β-catenin or Lamin-B1. (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be440badae467092b147d85660e07285