Receptor and ligand-based 3D-QSAR study on a series of nonsteroidal anti-inflammatory drugs

Autor: Souhila Bouaziz-Terrachet, Redouane Terrachet, Safia Taïri-Kellou

Publikováno v: Medicinal Chemistry Research. 22:1529-1537

Self-organizing molecular field analysis (SOMFA) has been used to study the correlation between the molecular properties of a series of 33 stilbene analogs and the cyclooxygenase-2 (COX-2) inhibitory activities. Thus, two different alignments and fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcdd54b716ba3a73807b28d48f79b427
https://doi.org/10.1007/s00044-012-0174-z

Analysis of c-Met Kinase Domain Complexes: A New Specific Catalytic Site Receptor Model for Defining Binding Modes of ATP-Competitive Ligands

Autor: Rosanna Dono, Yasmine Asses, Safia Taïri-Kellou, Bernard Maigret, Flavio Maina, Vincent Leroux

Publikováno v: Chemical Biology and Drug Design
Chemical Biology and Drug Design, 2009, 74 (6), pp.560-570. ⟨10.1111/j.1747-0285.2009.00895.x⟩
Chemical Biology and Drug Design, Wiley, 2009, 74 (6), pp.560-70. ⟨10.1111/j.1747-0285.2009.00895.x⟩
Chemical Biology and Drug Design, 2009, 74 (6), pp.560-70. ⟨10.1111/j.1747-0285.2009.00895.x⟩
Chemical Biology and Drug Design, Wiley, 2009, 74 (6), pp.560-570. ⟨10.1111/j.1747-0285.2009.00895.x⟩

International audience; The receptor tyrosine kinase c-Met have multiple roles during cancer development and is currently considered as an important target for molecularly targeted therapies. Structural knowledge of how compounds interact on c-Met ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c756419ad0f7a1f3374a39f9f667837
https://hal.inria.fr/inria-00435159