Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Safia Costes"'
Autor:
Nour Zaïmia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113326- (2023)
Summary: Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets
Externí odkaz:
https://doaj.org/article/54b6448a593b4cfe8fe94037568cf310
Autor:
Matthew R. Brown, Damien Laouteouet, Morgane Delobel, Orianne Villard, Christophe Broca, Gyslaine Bertrand, Anne Wojtusciszyn, Stéphane Dalle, Magalie A. Ravier, Aleksey V. Matveyenko, Safia Costes
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-12 (2022)
Abstract Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles. Howe
Externí odkaz:
https://doaj.org/article/b8f90d9713164bc79d87bd9e85ebe040
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5303 (2021)
Type 2 diabetes (T2D) is characterized by chronic hyperglycemia secondary to the decline of functional beta-cells and is usually accompanied by a reduced sensitivity to insulin. Whereas altered beta-cell function plays a key role in T2D onset, a decr
Externí odkaz:
https://doaj.org/article/441926b7fe5b4cafa1babc664aeda07c
Autor:
Matthew R. Brown, Damien Laouteouet, Morgane Delobel, Orianne Villard, Christophe Broca, Gyslaine Bertrand, Anne Wojtusciszyn, Stéphane Dalle, Magalie A. Ravier, Aleksey V. Matveyenko, Safia Costes
Publikováno v:
Cell Death and Disease
Cell Death and Disease, 2022, 13 (4), pp.353. ⟨10.1038/s41419-022-04767-z⟩
Cell Death and Disease, 2022, 13 (4), pp.353. ⟨10.1038/s41419-022-04767-z⟩
Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles. However, the
Autor:
Damien Laouteouet, Magalie A. Ravier, Aleksey V. Matveyenko, Morgane Delobel, Gyslaine Bertrand, Stephane Dalle, Safia Costes
Publikováno v:
Diabetes. 68
The circadian clock regulates diverse cellular and molecular rhythms employing CLOCK-BMAL1 transcriptional heterodimer with nuclear receptor REV-ERBα (encoded by gene Nr1d1) playing an important role as a clock repressor through modulation of Bmal1
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1957
Novel findings reveal important functional roles for β-arrestin 1 and β-arrestin 2 in the regulation of insulin secretion, β-cell survival, and β-cell mass plasticity not only by glucose but also by G-protein-coupled receptors, such as the glucag
Publikováno v:
Methods in Molecular Biology
Methods in Molecular Biology, 1957, springer; Humana Press, pp.345-364, 2019, Beta-arrestins, 978-1-4939-9157-0. ⟨10.1007/978-1-4939-9158-7_22⟩
Beta-Arrestins ISBN: 9781493991570
Methods in Molecular Biology, 1957, springer; Humana Press, pp.345-364, 2019, Beta-arrestins, 978-1-4939-9157-0. ⟨10.1007/978-1-4939-9158-7_22⟩
Beta-Arrestins ISBN: 9781493991570
International audience; Novel findings reveal important functional roles for β-arrestin 1 and β-arrestin 2 in the regulation of insulinsecretion, β-cell survival, and β-cell mass plasticity not only by glucose but also by G-protein-coupledrecepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bab9403ccbecb641939d9fa144e74b
https://hal.archives-ouvertes.fr/hal-02397739/file/postprint.pdf
https://hal.archives-ouvertes.fr/hal-02397739/file/postprint.pdf
Autor:
Jacqueline F. Rivera, Safia Costes, Jonathan D. Hoang, Alexandra E. Butler, Tatyana Gurlo, Megan Cory, Peter C. Butler
Publikováno v:
Molecular endocrinology (Baltimore, Md.), vol 30, iss 4
The islet in type 2 diabetes is characterized by β-cell loss, increased β-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). When protein misfolding protective mechanisms are overcome, human IAPP (h-IAPP) forms membran
Autor:
Safia Costes
Publikováno v:
Current opinion in pharmacology. 43
The islet in type 2 diabetes is characterized by beta-cell dysfunction and deficit, increased beta-cell apoptosis and amyloid deposits that derived from islet amyloid polypeptide (IAPP). In species such as humans that are vulnerable to developing typ
Autor:
Jacques Pouysségur, Dany Muller, Safia Costes, Michele Leduc, Joy Richard, Gyslaine Bertrand, Vincent Compan, Jean-François Tanti, Julia Mathieu, Stéphane Dalle, Annie Varrault, Gilles Pagès, Magalie A. Ravier
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2017, 60 (10), pp.1999-2010. ⟨10.1007/s00125-017-4356-6⟩
Diabetologia, Springer Verlag, 2017, 60 (10), pp.1999-2010. ⟨10.1007/s00125-017-4356-6⟩
Insufficient insulin secretion from pancreatic beta cells, which is associated with a decrease in beta cell mass, is a characteristic of type 2 diabetes. Extracellular signal-related kinase 1 and 2 (ERK1/2) inhibition in beta cells has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428a800626d18251c0bfbcc256d0eba4
https://hal.umontpellier.fr/hal-02073008
https://hal.umontpellier.fr/hal-02073008