Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association.

Autor: Chu A; Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada., Yao Y; Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada., Saffi GT; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada., Chung JH; Faculty of Arts and Science, Queen University, Kingston, ON K7L 3N9, Canada., Botelho RJ; Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON M5G 2A7, Canada., Glibowicka M; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Deber CM; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M1C 1A4, Canada., Manolson MF; Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada.; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M1C 1A4, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 02; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 02.

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.

Autor: Saffi GT; Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada.; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada., Tang E; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada., Mamand S; Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada.; Polytechnic Research Center, Erbil Polytechnic University, Kurdistan Regional Government, Erbil, Kurdistan., Inpanathan S; Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada.; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada., Fountain A; Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada.; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada., Salmena L; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Botelho RJ; Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada.; Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.

Publikováno v: PloS one [PLoS One] 2021 Nov 23; Vol. 16 (11), pp. e0259313. Date of Electronic Publication: 2021 Nov 23 (Print Publication: 2021).

Amyloid-β Inhibits PDGFβ Receptor Activation and Prevents PDGF-BBInduced Neuroprotection.

Autor: Liu H; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Saffi GT; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Vasefi MS; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Choi Y; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Kruk JS; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Ahmed N; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Gondora N; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Mielke J; Faculty of Science, and the School of Public Health and Health Systems, Faculty of Applied Health Science, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Leonenko Z; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada.; Physics and Astronomy, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada., Beazely MA; The Departments of Biology, University of Waterloo School of Pharmacy, Kitchener, ON, N2G IC5, Canada.

Publikováno v: Current Alzheimer research [Curr Alzheimer Res] 2018; Vol. 15 (7), pp. 618-627.