Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Safak Isin"'
Autor:
Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Cryptochromes are transcriptional regulators of the circadian clock in mammals, and genetic loss of cryptochromes reduces p53-associated cancer risk in mice. Here the authors report the discovery of small molecule M47, which destabilizes cryptochrome
Externí odkaz:
https://doaj.org/article/74ebf0d9b13b4f24b201b187236a7cc6
Structure-based design and classifications of small molecules regulating the circadian rhythm period
Autor:
Seref Gul, Fatih Rahim, Safak Isin, Fatma Yilmaz, Nuri Ozturk, Metin Turkay, Ibrahim Halil Kavakli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Circadian rhythm is an important mechanism that controls behavior and biochemical events based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is associated with different diseases such as cancer, mood disorders,
Externí odkaz:
https://doaj.org/article/53751473eb374211a46f13f33d21e0bd
Autor:
Saba Selvi, Yasemin Kubra Akyel, Mustafa Guzel, Fatih Aygenli, Nuri Ozturk, Ali Cihan Taskin, Safak Isin, Durisehvar Ozer Unal, Ibrahim Danis, Metin Turkay, Ozgecan Savlug Ipek, Seref Gul, Zeynep Melis Gul, Narin Ozturk, Alper Okyar, Tuba Korkmaz, Ibrahim Halil Kavakli
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous level of the CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03a2d1288d0a764da3ba1cf2f8bf2a8d
https://doi.org/10.1101/2021.07.21.453206
https://doi.org/10.1101/2021.07.21.453206
Autor:
Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakli
Publikováno v:
Nature Communications
Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a15ca742cbd52392b0eafb83cb5d0e
https://pubmed.ncbi.nlm.nih.gov/36347873
https://pubmed.ncbi.nlm.nih.gov/36347873