Human neurotropic polyomavirus, JC virus, late coding region encodes a novel nuclear protein, ORF4, which targets the promyelocytic leukemia nuclear bodies (PML-NBs) and modulates their reorganization

Autor: Saribas, A. Sami, Bellizzi, Anna, Wollebo, Hassen S., Beer, Thomas, Tang, Hsin-Yao, Safak, Mahmut

Publikováno v: In Virology October 2023 587

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Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content

Autor: Safak Mahmut, White Martyn K, Saribas Abdullah S, Sariyer Ilker K

Publikováno v: Virology Journal, Vol 8, Iss 1, p 255 (2011)

Abstract Background Human polyomavirus JC (JCV) is the etiologic agent of a brain disease, known as progressive multifocal leukoencephalopathy (PML). The JCV genome encodes a small multifunctional phospho-protein, agnoprotein, from the late coding re

Externí odkaz: https://doaj.org/article/3487021a69c249da9bd36aed6a266999

Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein

Autor: Coric, Pascale, Saribas, A Sami, Abou-Gharbia, Magid, Childers, Wayne, Condra, Jon, White, Martyn, Safak, Mahmut, Bouaziz, Serge, Saribas, A. Sami

Publikováno v: Journal of Cellular Biochemistry
Journal of Cellular Biochemistry, Wiley, 2017, 118 (10), pp.3268-3280. ⟨10.1002/jcb.25977⟩
Journal of Cellular Biochemistry, 2017, 118 (10), pp.3268-3280. ⟨10.1002/jcb.25977⟩

International audience; Agnoprotein is an important regulatory protein of the human polyoma JC virus (JCV) and plays critical roles during the viral replication cycle. It forms highly stable dimers and oligomers through its Leu/Ile/Phe-rich domain, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5a0edc67baaf2e768c9a86eecbee12
https://hal.archives-ouvertes.fr/hal-02122339