Anti-Idiotype scFv Localizes an Autoepitope in the Globular Domain of C1q

Autor: Miroslav Rangelov, Ivanka Tsacheva, Hristo Georgiev, Nadezhda Todorova, Vishnya Stoyanova, Daniela Dimitrova, Vanya Bogoeva, Anna Yordanova, Katerina Stoyanova, Ginka Nikolova, Safa Mohedin

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8288, p 8288 (2021)

We addressed the issue of C1q autoantigenicity by studying the structural features of the autoepitopes recognized by the polyclonal anti-C1q antibodies present in Lupus Nephritis (LN) sera. We used six fractions of anti-C1q as antigens and selected a

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