Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Safa Daoud"'
Autor:
Safa Daoud, Mutasem Taha
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Activity cliffs (ACs) are pairs of structurally similar molecules with significantly different affinities for a biotarget, posing a challenge in computer-assisted drug discovery. This study focuses on protein kinases, significant therapeutic
Externí odkaz:
https://doaj.org/article/7164499904a642068bb49fcf2c975125
Autor:
Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod, Reem Ali Hamed, Dima Awajan, Sara Feras Abuarab, Lena Hisham Odeh, Samar Khater, Lina T. Al Kury
Publikováno v:
Molecules, Vol 27, Iss 15, p 4818 (2022)
Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells durin
Externí odkaz:
https://doaj.org/article/fd6107d229be45a2936c0a07d141fdc4
Publikováno v:
Molecules, Vol 26, Iss 9, p 2506 (2021)
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin
Externí odkaz:
https://doaj.org/article/711760dac8004b369a97a54866d255be
Publikováno v:
Molecules, Vol 25, Iss 22, p 5319 (2020)
Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a prior
Externí odkaz:
https://doaj.org/article/b45f4c3a087a401ba62116e257fb1c0e
Publikováno v:
Pharmacy Practice. 20:01-10
The coronavirus disease identified in 2019 (COVID-19) led to extreme actions being taken by the governments to restrict the spread of this virus. Closure of schools, sport clubs and playgrounds were among these actions; children had to stay indoors a
Publikováno v:
Molecular Informatics.
Publikováno v:
The Open Medicinal Chemistry Journal. 17
Aim The aim of this study is to investigated the potential inhibitory activity of asenapine against central nervous system CaMKII isozymes as a potential repurposing study using docking experiments and enzymatic assay. Background The Ca2+/calmodulin-
Publikováno v:
RSC Advances. 12:10686-10700
Ligand-based pharmacophores, ligand–receptor contact fingerprints, physicochemical descriptors and machine learning were combined to probe binding of potent CLK4 antagonists. GFA-SVR gave the best model. Virtual screening identified 3 nanomolar hit
Pneumocystis jirovecii pneumonia (PCP), caused by fungal species named Pneumocystis jirovecii, is a frequent opportunistic infection in those with human immunodeficiency virus (HIV) infection. However, PCP has been documented in immunocompetent patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d367c870a2c2397b1d5d90def08c55
Autor:
Taher S. Ababneh, Tareq M. A. Al-Shboul, Taghreed M. A. Jazzazi, Safa Daoud, Mohammad Jamal A. Shammout, Mohammad El-khateeb, Wamidh H. Talib, Aissar K. Tanash, Mohammad I. Alomari
Publikováno v:
Polish Journal of Chemical Technology, Vol 23, Iss 1, Pp 7-15 (2021)
Four new symmetrical Schiff bases derived from 2,2’-diamino-4,4’-dimethyl-1,1’-biphenyl-salicylaldehyde have been synthesized and characterized by elemental analysis and different spectroscopic techniques. The reaction of 2,2’-diamino-4,4’-