Zobrazeno 1 - 10
of 421
pro vyhledávání: '"Saetrom P"'
Autor:
Ilona Urbarova, Anne Heidi Skogholt, Yi-Qian Sun, Xiao-Mei Mai, Bjørn Henning Grønberg, Torkjel Manning Sandanger, Pål Sætrom, Therese Haugdahl Nøst
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represent
Externí odkaz:
https://doaj.org/article/2350ae4e38d8450598e4b8ff788d1667
Autor:
Maria Letizia Potenza, Stefan Blankvoort, Miguel M. Carvalho, Joachim S. Grimstvedt, Valentina Di Maria, Kristian Moan, Rajeevkumar Raveendran Nair, Marcus S. Flatset, Qiangwei Zhang, Laurent F. Thomas, Francois P. Pauzin, Rodolfo Da Silva Mazzarini Baldinotti, Giulia Quattrocolo, Clive R. Bramham, Pål Sætrom, Menno P. Witter, Clifford G. Kentros
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in the brain. However, native promoters cannot achieve this because while most genes are expressed in the
Externí odkaz:
https://doaj.org/article/75c3588560e24daa9e9cd2efe9d93a58
Autor:
Ioannis Konstantinidis, Pål Sætrom, Marine S. O. Brieuc, Kjetill S. Jakobsen, Hannes Liedtke, Caroline Pohlmann, Thomais Tsoulia, Jorge M. O. Fernandes
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
ABSTRACTPhenotypic plasticity of metabolism and growth are essential for adaptation to new environmental conditions, such as those experienced during domestication. Epigenetic regulation plays a key role in this process but the underlying mechanisms
Externí odkaz:
https://doaj.org/article/19db233e1a704b3f94fe74621d767868
Publikováno v:
BMC Genomics, Vol 13, Iss 1, p 372 (2012)
Abstract Background Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) ident
Externí odkaz:
https://doaj.org/article/0b5b28a9c30f4fd8b1f4a6427b4e349e
Publikováno v:
BMC Biology, Vol 9, Iss 1, p 80 (2011)
Abstract Background Transcription factor binding to DNA requires both an appropriate binding element and suitably open chromatin, which together help to define regulatory elements within the genome. Current methods of identifying regulatory elements,
Externí odkaz:
https://doaj.org/article/b781abe5bb9f45938f5340631e93764a
Autor:
Sætrom Pål, Saito Takaya
Publikováno v:
BMC Bioinformatics, Vol 11, Iss 1, p 612 (2010)
Abstract Background Despite experiments showing that the number of microRNA (miRNA) target sites is critical for miRNA targeting, most existing methods focus on identifying individual miRNA target sites and do not model contributions of multiple targ
Externí odkaz:
https://doaj.org/article/83d97372083a4b999cea252181ee09b0
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract The mechanisms underlying the fast genome evolution that occurs during animal domestication are poorly understood. Here, we present a genome-wide epigenetic dataset that quantifies DNA hydroxymethylation at single nucleotide resolution among
Externí odkaz:
https://doaj.org/article/cb25a8d4e47d4e5eb3a4bcc18f7a5d82
Autor:
Therese Haugdahl Nøst, Anne Heidi Skogholt, Ilona Urbarova, Robin Mjelle, Erna‐Elise Paulsen, Tom Dønnem, Sigve Andersen, Maria Markaki, Oluf Dimitri Røe, Mikael Johansson, Mattias Johansson, Bjørn Henning Grønberg, Torkjel Manning Sandanger, Pål Sætrom
Publikováno v:
Molecular Oncology, Vol 17, Iss 2, Pp 312-327 (2023)
Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluat
Externí odkaz:
https://doaj.org/article/f11aa83983e74d5985fd3b02450edf55
Autor:
Lundberg Cathryn, Snøve Ola, Sætrom Pål, Smith David D, Rivas Guillermo E, Glackin Carlotta, Larson Garrett P
Publikováno v:
BMC Bioinformatics, Vol 9, Iss 1, p 63 (2008)
Abstract Background Gene expression measurements from breast cancer (BrCa) tumors are established clinical predictive tools to identify tumor subtypes, identify patients showing poor/good prognosis, and identify patients likely to have disease recurr
Externí odkaz:
https://doaj.org/article/2436caa752004affac8d6f92c79dab51
Publikováno v:
BMC Bioinformatics, Vol 8, Iss 1, p 23 (2007)
Abstract Background Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and unrelated sequences and these studies have introduced several t
Externí odkaz:
https://doaj.org/article/5c7899ebef1c4e6486e7dba7581d7a8d