POSA143 Budget Impact Analysis for the Use of Dupilumab in Patients with Severe Asthma in Colombia

Autor: Londono, S, Saenz, SA, Avila, MP

Publikováno v: In Value in Health January 2022 25(1) Supplement:S62-S62

High-Performance Detectors Based on the Novel Electronic and Optoelectronic Properties of Crystalline 2D van der Waals Solids

Autor: Saenz Saenz, Gustavo Alberto

In this work, we study the properties and device applications of MoS2, black phosphorus, MoOx, and NbSe2. We first start with the design, fabrication, and characterization of ultra-high responsivity photodetectors based on mesoscopic multilayer MoS2.

Externí odkaz: https://digital.library.unt.edu/ark:/67531/metadc1703294/

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

Autor: Saenz SA; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Local A; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America., Carr T; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Shakya A; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America., Koul S; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America., Hu H; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Chourb L; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Stedman J; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Malley J; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America., D'Agostino LA; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Shanmugasundaram V; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Malona J; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America., Schwartz CE; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America., Beebe L; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Clements M; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America., Rajaraman G; Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America., Cho J; Immunology & Inflammation, Celgene Corporation, Cambridge, Massachusetts, United States of America., Jiang L; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Dubrovskiy A; Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Kreilein M; Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America., Shimanovich R; Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Hamann LG; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America., Escoubet L; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America., Ellis JM; Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.

Publikováno v: PloS one [PLoS One] 2021 Nov 09; Vol. 16 (11), pp. e0248034. Date of Electronic Publication: 2021 Nov 09 (Print Publication: 2021).

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Autor: Monticelli LA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Buck MD; Department of Immunometabolism, Max Plank Institute of Immunobiology and Epigenetics, Freiburg, Germany., Flamar AL; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Saenz SA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Tait Wojno ED; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Yudanin NA; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Osborne LC; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Hepworth MR; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Tran SV; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA., Rodewald HR; Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Shah H; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Cross JR; Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Diamond JM; Division of Cardiovascular Surgery, Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cantu E; Division of Cardiovascular Surgery, Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Christie JD; Division of Cardiovascular Surgery, Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Pearce EL; Department of Immunometabolism, Max Plank Institute of Immunobiology and Epigenetics, Freiburg, Germany., Artis D; Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York, USA.

Publikováno v: Nature immunology [Nat Immunol] 2016 Jun; Vol. 17 (6), pp. 656-65. Date of Electronic Publication: 2016 Apr 04.

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

Autor: Brestoff JR; 1] Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA [2] Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Kim BS; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Saenz SA; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Stine RR; Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Monticelli LA; 1] Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA [2] Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Sonnenberg GF; Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA., Thome JJ; 1] Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York 10032, USA [2] Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA., Farber DL; 1] Columbia Center for Translational Immunology, Columbia University Medical Center, New York, New York 10032, USA [2] Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA [3] Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA., Lutfy K; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, USA., Seale P; Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Artis D; 1] Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA [2] Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Publikováno v: Nature [Nature] 2015 Mar 12; Vol. 519 (7542), pp. 242-6. Date of Electronic Publication: 2014 Dec 22.