Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Saeko Hoshikawa"'
Autor:
Yoshinori Nakagawa, Saeko Hoshikawa, Kazuki Morohoshi, Kouki Mori, Yurie Takahashi, Sadayoshi Ito, Hiroshi Ozaki, Katsumi Yoshida, Michiko Osone
Publikováno v:
Autoimmunity. 44:490-495
FTY720 is an immunomodulator that alters migration and homing of lymphocytes via sphingosine 1-phosphate receptors. This compound has been shown to be effective in suppressing autoimmune diseases in experimental and clinical settings. In the present
Autor:
Hiroshi Ozaki, Masahiro Ohta, Sadayoshi Ito, Chizuko Kuriyama, Yoshinori Nakagawa, Saeko Hoshikawa, Katsumi Yoshida, Kouki Mori, Minoru Inoue
Publikováno v:
Endocrine Journal. 58:59-63
Red blood cell (RBC) zinc (Zn) concentration reflects a patient's mean thyroid hormone level over the preceding several months. The aim of this study was to examine whether RBC Zn level can be used as an indicator to distinguish painless thyroiditis-
Autor:
Masahiko Mihara, Katsumi Yoshida, Saeko Hoshikawa, Hiroshi Ozaki, Yoshiyuki Ohsugi, Kouki Mori, Yoshinori Nakagawa, Sadayoshi Ito
Publikováno v:
Autoimmunity. 42:228-234
We explored the role of interleukin-6 (IL-6) in the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis, using anti-mouse IL-6 receptor antibody (MR16-1). Thyroiditis was induced by iodide
Autor:
Kouki Mori, Sadayoshi Ito, Hiroshi Ozaki, Yoshinori Nakagawa, Katsumi Yoshida, Saeko Hoshikawa
Publikováno v:
Endocrine Journal. 55:113-119
Thyrotoxic periodic paralysis (TPP) is mainly associated with Graves' disease but rarely with autonomously functioning thyroid nodule (AFTN). We herein report a case of AFTN associated with TPP in which the latter resolved after (131) I therapy for t
Autor:
Sadayoshi Ito, Yoshinori Nakagawa, Saeko Hoshikawa, Kouki Mori, Hiroshi Ozaki, Jun Ichi Tani, Katsumi Yoshida
Publikováno v:
Clinical Immunology. 126:97-103
We evaluated the effects of angiotensin II (Ang II) blockers, losartan, an Ang II receptor blocker, and enalapril, an angiotensin converting enzyme inhibitor, on the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal mod
Autor:
Chiho Watanabe, Saeko Hoshikawa, Yoshinori Nakagawa, Sadayoshi Ito, Kouki Mori, Katsumi Yoshida, Hiroshi Ozaki
Publikováno v:
Toxicology. 237:203-209
We have recently reported that methylmercury (MeHg) inhibits type II iodothyronine 5'-deiodinase (D2) activity in mouse neuroblastoma NB41A3 cells. In the present study, we determined the biological significance of D2 inhibition by MeHg. GH3 rat pitu
Autor:
Sadayoshi Ito, Chiho Watanabe, Masahiko Satoh, Saeko Hoshikawa, Minoru Yoshida, Kouki Mori, Katsumi Yoshida
Publikováno v:
Toxicology. 228:77-84
Perinatal exposure to cadmium (Cd) or methylmercury (MeHg) results in impaired neurodevelopment. Thyroid hormone is essential for normal brain development. However, the issue whether Cd or MeHg, especially at low doses, interrupts thyroid hormone act
Publikováno v:
Toxicology Letters. 161:96-101
Methylmercury (MeHg) is a well-known neurotoxicant and prenatal exposure to MeHg results in severe brain damage. Since MeHg has a high affinity for thiol groups, we sought to determine whether MeHg inhibited type II iodothyronine deiodinase (D2) acti
Experimental autoimmune thyroiditis in nonobese diabetic mice lacking interferon regulatory factor-1
Autor:
Zhongtian Jin, Sadayoshi Ito, Kouki Mori, Susumu Satomi, Saeko Hoshikawa, Jun Ichi Tani, Katsumi Yoshida, Keisei Fujimori, Jo Satoh
Publikováno v:
Clinical Immunology. 113:187-192
Interferon regulatory factor-1 (IRF-1) is pivotal in the regulation of interferon (IFN)-mediated immune reactions, and studies suggest that IRF-1 is involved in the development of autoimmune diseases. IRF-1+/+, +/-, and -/- nonobese diabetic (NOD) mi
Autor:
Katsumi Yoshida, Saeko Hoshikawa, Kouki Mori, Sadayoshi Ito, Nobuko Kaise, Yoshinori Nakagawa
Publikováno v:
Thyroid. 14:155-160
Familial dysalbuminemic hyperthyroxinemia (FDH) is a familial autosomal dominant syndrome caused by abnormal albumin with an increased affinity for thyroxine (T4). Two types of mutations in the albumin gene, replacing the normal arginine 218 with a h