Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Saeed Farjami"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008463 (2020)
Cerebellar stellate cells (CSCs) are spontaneously active, tonically firing (5-30 Hz), inhibitory interneurons that synapse onto Purkinje cells. We previously analyzed the excitability properties of CSCs, focusing on four key features: type I excitab
Externí odkaz:
https://doaj.org/article/81be1e8618154ace93b05494cc0e168c
Autor:
Amin Akhshi, Myriah Haggard, Mariana M. Marquez, Saeed Farjami, Maurice J. Chacron, Anmar Khadra
Neurons ubiquitously display heterogeneities in spiking activity even within a given cell type. To date, the relative contributions of extrinsic mechanisms (e.g., synaptic bombardment) and intrinsic mechanisms (e.g., conductances, cell morphology) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba91aca01cccc0f91e5d5e1c6304b2cc
https://doi.org/10.1101/2023.01.03.521866
https://doi.org/10.1101/2023.01.03.521866
Publikováno v:
Neural Computation. 32:626-658
Cerebellar stellate cells form inhibitory synapses with Purkinje cells, the sole output of the cerebellum. Upon stimulation by a pair of varying inhibitory and fixed excitatory presynaptic inputs, these cells do not respond to excitation (i.e., do no
Autor:
Vsevolod J. Makeev, Robert N. Kelsh, Karen Camargo Sosa, Saeed Farjami, Andrea Rocco, Jonathan H.P. Dawes
Publikováno v:
Kelsh, R N, Sosa, K C, Farjami, S, Makeev, V, Dawes, J H P & Rocco, A 2021, ' Cyclical fate restriction : A new view of neural crest cell fate specification ', Development (Cambridge), vol. 148, no. 22, dev176057 . https://doi.org/10.1242/dev.176057
Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive f
Publikováno v:
Farjami, S, Camargo Sosa, K, Dawes, J H P, Kelsh, R N & Rocco, A 2021, ' Novel Generic Models for Differentiating Stem Cells Reveal Oscillatory Mechanisms ', Journal of the Royal Society, Interface, vol. 18, no. 183, 20210442 . https://doi.org/10.1098/rsif.2021.0442
Journal of the Royal Society Interface
Journal of the Royal Society Interface
Understanding cell fate selection remains a central challenge in developmental biology. We present a class of simple yet biologically-motivated mathematical models for cell differentiation that generically generate oscillations and hence suggest alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acd1bf65cfde9e49d70cf0aed902934
https://purehost.bath.ac.uk/ws/files/225932327/Farjami_etal_2105.13702v2.pdf
https://purehost.bath.ac.uk/ws/files/225932327/Farjami_etal_2105.13702v2.pdf
Publikováno v:
The European Physical Journal Special Topics. 227:603-614
Multi-spike bursting of the membrane potential is understood to be a key mechanism for cell signalling in neurons. During the active phase of a burst, the voltage potential across the cell membrane exhibits a series of spikes. This is followed by a s
Publikováno v:
SIAM Journal on Applied Dynamical Systems. 17:350-379
The behavior of systems with fast and slow time scales is organized by families of locally invariant slow manifolds. Recently, numerical methods have been developed for the approximation of attract...
Publikováno v:
The European Physical Journal Special Topics. 225:2601-2612
Many models of neuronal activity exhibit complex oscillations in response to an input from other neurons in a network or to an input from a stimulus. We consider the effect of a single short stimulus on a simple model designed to mimic some features
Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008463 (2020)
PLoS Computational Biology
PLoS Computational Biology
Cerebellar stellate cells (CSCs) are spontaneously active, tonically firing (5-30 Hz), inhibitory interneurons that synapse onto Purkinje cells. We previously analyzed the excitability properties of CSCs, focusing on four key features: type I excitab
Publikováno v:
Communications in Nonlinear Science and Numerical Simulation. 82:105014
Cerebellar stellate cells are inhibitory molecular interneurons that regulate the firing properties of Purkinje cells, the sole output of cerebellar cortex. Recent evidence suggests that these cells exhibit temporal increase in excitability during wh