Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children

Autor: Svea Stratmann, Mattias Vesterlund, Husen M. Umer, Saeed Eshtad, Aron Skaftason, Morten Krogh Herlin, Christer Sundström, Anna Eriksson, Martin Höglund, Josefine Palle, Jonas Abrahamsson, Kirsi Jahnukainen, Monica Cheng Munthe-Kaas, Bernward Zeller, Katja Pokrovskaja Tamm, Cecilia Lindskog, Lucia Cavelier, Janne Lehtiö, Linda Holmfeldt

Publikováno v: Stratmann, S, Vesterlund, M, Umer, H M, Eshtad, S, Skaftason, A, Herlin, M K, Sundström, C, Eriksson, A, Höglund, M, Palle, J, Abrahamsson, J, Jahnukainen, K, Munthe-Kaas, M C, Zeller, B, Tamm, K P, Lindskog, C, Cavelier, L, Lehtiö, J & Holmfeldt, L 2023, ' Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children ', Leukemia, vol. 37, no. 3, pp. 550–559 . https://doi.org/10.1038/s41375-022-01796-7
Leukemia

Despite improvement of current treatment strategies and novel targeted drugs, relapse and treatment resistance largely determine the outcome for acute myeloid leukemia (AML) patients. To identify the underlying molecular characteristics, numerous stu

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https://pure.au.dk/portal/da/publications/proteogenomic-analysis-of-acute-myeloid-leukemia-associates-relapsed-disease-with-reprogrammed-energy-metabolism-both-in-adults-and-children(ce2db4d1-e3de-43f1-90c3-0552268840be).html

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Autor: Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Oliver Mortusewicz, Varshni Rajagopal, Julian J Albers, Daniel W Hagey, Tove Bekkhus, Saeed Eshtad, Juan Miguel Baquero, Geoffrey Masuyer, Olov Wallner, Sarah Müller, Therese Pham, Camilla Göktürk, Azita Rasti, Sharda Suman, Raúl Torres-Ruiz, Antonio Sarno, Elisée Wiita, Evert J Homan, Stella Kar

Publikováno v: Nucleic Acids Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::1b96a4787958dae3873632e7ad65a12f

Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Autor: Ronnie P.-A. Berntsson, Aljona Saleh, Helge Gad, Martin Henriksson, Ingrid Almlöf, Cecilia E. Ström, Jordi Carreras Puigvert, Pål Stenmark, Fabienne Z. Gaugaz, Cecilia Lundin, Marie-Caroline Jacques-Cordonnier, Ulrika Warpman Berglund Thomas Helleday, Berglind Osk Einarsdottir, Roger Olofsson, Camilla Göktürk, Niklas Schultz, Maria Häggblad, Pawel Baranczewski, Anna-Lena Gustavsson, Olga Loseva, Per Artursson, Karl S. A. Vallin, Hanna Axelsson, Bo Lundgren, Tobias Koolmeister, Kia Strömberg, Christina Kalderén, Ulf Martens, Saeed Eshtad, Jonas Nilsson, Fredrik Johansson, Mikael Altun, Fredrik Jeppsson, Thomas Lundbäck, Evert Homan, Ann-Sofie Jemth, Martin Scobie, Anna Hagenkort, Lars Bräutigam, Annika Jenmalm Jensen, Andreas Höglund, Matthieu Desroses, Linda M. Svensson, Therese M. Pham, Richard Svensson, Kumar Sanjiv, Sylvain A. Jacques, Lars Hammarström, Elisee Wiita, Robert Gustafsson, Tatjana Djureinovic, Olov A. Wallner, Bastiaan Evers, Ingrid Granelli, Svante Vikingsson, Lars Johansson

Publikováno v: Nature. 544:508-508

Nature 508, 215–221 (2014); doi:10.1038/nature13181 In this Article, the structure of compound TH650 (4) in Fig. 4a was drawn incorrectly; the correct structure is shown as Fig. 1 to this Corrigendum. Preparative, spectroscopic and biological data

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https://doi.org/10.1038/nature22083

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

Autor: Torkild Visnes, Sean G. Rudd, Mikael Altun, Johan Boström, Saeed Eshtad, Z Mavajian, Thomas Helleday

Publikováno v: Oncogenesis

hMTH1 is an 8-oxodGTPase that prevents mis-incorporation of free oxidized nucleotides into genomic DNA. Base excision and mismatch repair pathways also restrict the accumulation of oxidized lesions in DNA by removing the mis-inserted 8-oxo-7,8-dihydr

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https://doi.org/10.1038/oncsis.2016.72

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Autor: Christina Kalderén, Fredrik Jeppsson, Karl S. A. Vallin, Hanna Axelsson, Evert Homan, Thomas Lundbäck, Martin Scobie, Ulrika Warpman Berglund, Per Artursson, Saeed Eshtad, Therese Pham, Lars Bräutigam, Bastiaan Evers, Thomas Helleday, Anna Hagenkort, Bo Lundgren, Richard Svensson, Anna-Lena Gustavsson, Niklas Schultz, Matthieu Desroses, Lars Hammarström, Maria Häggblad, Kumar Sanjiv, Elisee Wiita, Robert Gustafsson, Mikael Altun, Tobias Koolmeister, Aljona Saleh, Pawel Baranczewski, Jonas Nilsson, Sylvain A. Jacques, Andreas Höglund, Cecilia E. Ström, Martin Henriksson, Ingrid Almlöf, Fredrik Johansson, Pål Stenmark, Fabienne Z. Gaugaz, Tatjana Djureinovic, Berglind Osk Einarsdottir, Olov A. Wallner, Annika Jenmalm Jensen, Ronnie P.-A. Berntsson, Helge Gad, Ingrid Granelli, Svante Vikingsson, Linda M. Svensson, Kia Strömberg, Ann-Sofie Jemth, Marie-Caroline Jacques-Cordonnier, Jordi Carreras Puigvert, Roger Olofsson, Camilla Göktürk, Ulf Martens, Lars Johansson, Cecilia Lundin, Olga Loseva

Publikováno v: NATURE
Nature

Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although M

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