Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sae Woong Park"'
Autor:
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich, Dirk Schnappinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that rv1590, a gene
Externí odkaz:
https://doaj.org/article/3054e679f3564df091570ea68d735626
Autor:
Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Publikováno v:
eLife, Vol 11 (2022)
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tra
Externí odkaz:
https://doaj.org/article/22a97844641345f9a6ecfdcfcd9e9300
Autor:
Landys Lopez Quezada, Robert Smith, Tania J. Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold, Julia Roberts, Yan Ling, Sae Woong Park, Quyen Nguyen, Frank J. Schoenen, Kelin Li, Jean-Emmanuel Hugonnet, Michel Arthur, James C. Sacchettini, Carl Nathan, Jeffrey Aubé
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) transpeptidases by carbap
Externí odkaz:
https://doaj.org/article/4d560f0f64cb40cc8c57181a0b7ea41e
Autor:
Michael A. DeJesus, Elias R. Gerrick, Weizhen Xu, Sae Woong Park, Jarukit E. Long, Cara C. Boutte, Eric J. Rubin, Dirk Schnappinger, Sabine Ehrt, Sarah M. Fortune, Christopher M. Sassetti, Thomas R. Ioerger
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT For decades, identifying the regions of a bacterial chromosome that are necessary for viability has relied on mapping integration sites in libraries of random transposon mutants to find loci that are unable to sustain insertion. To date, the
Externí odkaz:
https://doaj.org/article/a77bd7f0cb4b428b9bb78ab3fcebcc71
Autor:
Jennifer L. Small, Sae Woong Park, Bavesh D. Kana, Thomas R. Ioerger, James C. Sacchettini, Sabine Ehrt
Publikováno v:
mBio, Vol 4, Iss 5 (2013)
ABSTRACT Mycobacterium tuberculosis depends on aerobic respiration for growth and utilizes an aa3-type cytochrome c oxidase for terminal electron transfer. Cytochrome c maturation in bacteria requires covalent attachment of heme to apocytochrome c, w
Externí odkaz:
https://doaj.org/article/07e11785900e4ca0bdf5870ec4ebc63f
Autor:
Sae Woong Park, Marcus Klotzsche, Daniel J Wilson, Helena I Boshoff, Hyungjin Eoh, Ujjini Manjunatha, Antje Blumenthal, Kyu Rhee, Clifton E Barry, Courtney C Aldrich, Sabine Ehrt, Dirk Schnappinger
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002264 (2011)
In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8-diaminopelargonic acid synthase, BioA. In biotin-free synthetic
Externí odkaz:
https://doaj.org/article/79f2ea7ff78e4942926faffb55966fd1
Publikováno v:
Journal of Microbiology. 61:297-315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee26fab4f7992bfba27e3b4c807d8342
https://doi.org/10.1007/s12275-023-00026-8
https://doi.org/10.1007/s12275-023-00026-8
Publikováno v:
Korean Journal of Ichthyology. 33:22-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f369289f2ee9182ad61599e90cc9eeb0
https://doi.org/10.35399/isk.33.1.4
https://doi.org/10.35399/isk.33.1.4
Autor:
Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbdaaff833d89e67d57cf24b3fca7109
https://doi.org/10.7554/elife.74419.sa2
https://doi.org/10.7554/elife.74419.sa2
Autor:
Clare M Smith, Richard E Baker, Megan K Proulx, Bibhuti B Mishra, Jarukit E Long, Sae Woong Park, Ha-Na Lee, Michael C Kiritsy, Michelle M Bellerose, Andrew J Olive, Kenan C Murphy, Kadamba Papavinasasundaram, Frederick J Boehm, Charlotte J Reames, Rachel K Meade, Brea K Hampton, Colton L Linnertz, Ginger D Shaw, Pablo Hock, Timothy A Bell, Sabine Ehrt, Dirk Schnappinger, Fernando Pardo-Manuel de Villena, Martin T Ferris, Thomas R Ioerger, Christopher M Sassetti
Publikováno v:
eLife, Vol 11 (2022)
The outcome of an encounter withMycobacterium tuberculosis(Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3701ffe12e408bba8a4df51fd94454
https://pubmed.ncbi.nlm.nih.gov/35361983
https://pubmed.ncbi.nlm.nih.gov/35361983