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Autor:
Raz Winiarsky, Sae Hahm, Jacob J. Steinberg, Michelle Golden, S B S Harley Dresner, David Podwall, Antonio Cajigas, Mark Moosikasuwan
Publikováno v:
Cancer Investigation. 21:53-67
Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically dig