A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

Autor: MacMathuna Padraic, Doran Peter P, Sadlier Denise, Bennett Gayle, Murray David W

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 50 (2011)

Abstract Background NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring the proliferation, mo

Externí odkaz: https://doaj.org/article/5d0f9354385646ffb67b2fce746ca232

Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis

Autor: Sadlier Denise M, Murray David W, Keating Dominic T, Butler Joseph S, Hurson Conor J, O'Byrne John M, Doran Peter P

Publikováno v: BMC Musculoskeletal Disorders, Vol 8, Iss 1, p 12 (2007)

Abstract Background Osteoporosis, a disease of decreased bone mineral density represents a significant and growing burden in the western world. Aging population structure and therapeutic use of glucocorticoids have contributed in no small way to the

Externí odkaz: https://doaj.org/article/40edd498395c48c38e3f325901cd5700

The effect of obesity on acute kidney injury after cardiac surgery

Autor: O'Sullivan, Katie E., Byrne, John S., Hudson, Amy, Murphy, Anna Marie, Sadlier, Denise M., Hurley, John P.

Publikováno v: In The Journal of Thoracic and Cardiovascular Surgery December 2015 150(6):1622-1628

Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Autor: Smyth, Laura J, Dahlström, Emma H, Syreeni, Anna, Kerr, Katie, Kilner, Jill, Doyle, Ross, Brennan, Eoin, Nair, Viji, Fermin, Damian, Nelson, Robert G, Looker, Helen C, Wooster, Christopher, Andrews, Darrell, Anderson, Kerry, McKay, Gareth J, Cole, Joanne B, Salem, Rany M, Conlon, Peter J, Kretzler, Matthias, Hirschhorn, Joel N, Sadlier, Denise, Godson, Catherine, Florez, Jose C, GENIE consortium, Forsblom, Carol, Maxwell, Alexander P, Groop, Per-Henrik, Sandholm, Niina, McKnight, Amy Jayne

Publikováno v: Smyth, L J, Dahlström, E H, Syreeni, A, Kerr, K, Kilner, J, Doyle, R, Brennan, E, Nair, V, Fermin, D, Nelson, R G, Looker, H C, Wooster, C, Andrews, D, Anderson, K, McKay, G J, Cole, J B, Salem, R M, Conlon, P J, Kretzler, M, Hirschhorn, J N, Sadlier, D, Godson, C, Florez, J C, GENIE Consortium, Forsblom, C, Maxwell, A P, Groop, P H, Sandholm, N & McKnight, A J 2022, ' Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease ', Nature Communications, vol. 13, 7891 . https://doi.org/10.1038/s41467-022-34963-6
Nature communications, vol 13, iss 1

Type 1 diabetes affects over nine million individuals globally, with approximately 40% developing diabetic kidney disease. Emerging evidence suggests that epigenetic alterations, such as DNA methylation, are involved in diabetic kidney disease. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93872e02e57d5287f43ad757fb5f5e30
https://pure.qub.ac.uk/en/publications/4a97ab7f-894d-4f4e-9ed7-f7ebb2e90205

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