Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin.

Autor: Rasicci DV; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, United States., Tiwari P; Department of Radiology, Division of Cell Biology and Imaging, UMass Chan Medical School, Worcester, United States., Bodt SML; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, United States., Desetty R; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, United States., Sadler FR; Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, United States., Sivaramakrishnan S; Department of Genetics, Cell Biology, and Development, University of Minnesota Twin Cities, Minneapolis, United States., Craig R; Department of Radiology, Division of Cell Biology and Imaging, UMass Chan Medical School, Worcester, United States., Yengo CM; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, United States.

Publikováno v: ELife [Elife] 2022 Nov 24; Vol. 11. Date of Electronic Publication: 2022 Nov 24.