Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sadiya N. Addo"'
Autor:
Vladimir, Ivanov, Su-Peng, Yeh, Jiri, Mayer, Lalit, Saini, Ali, Unal, Michael, Boyiadzis, David M, Hoffman, Kingston, Kang, Sadiya N, Addo, Wellington L, Mendes, Amir T, Fathi
Publikováno v:
Future Oncology. 18:2879-2889
Prevention of relapse is a major therapeutic challenge and an unmet need for patients with acute myeloid leukemia (AML). Venetoclax is a highly selective, potent, oral BCL-2 inhibitor that induces apoptosis in AML cells. When combined with azacitidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb6064be00ab0e720647ccc93f64c1
https://doi.org/10.2217/fon-2022-0450
https://doi.org/10.2217/fon-2022-0450
Patients with hormone-refractory prostate cancer (HRPC) have an estimated median survival of only 10 months because of acquired drug resistance, urging the need to develop therapies against the drug-resistant HRPC phenotype. Accumulating evidence sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04bf604b7924be7e2b7d6335cf1220de
https://doi.org/10.1158/0008-5472.c.6497547
https://doi.org/10.1158/0008-5472.c.6497547
Supplementary Data from WL-276, an Antagonist against Bcl-2 Proteins, Overcomes Drug Resistance and Suppresses Prostate Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4230eb6c6ec99545f93b1ca32423cfff
https://doi.org/10.1158/0008-5472.22374675.v1
https://doi.org/10.1158/0008-5472.22374675.v1
Autor:
Ning Sun, Min Hu, Marc H Domanus, Mufeng Hu, Diya Mitra, Jessica E. Hutti, Miller Christopher P, Namjin Chung, Charles Lu, Sadiya N Addo, Sakina Petiwala
BackgroundGenome-wide CRISPR-Cas9 essentiality screening represents a powerful approach to identify genetic vulnerabilities in cancer cells. Here, we applied this technology and designed a strategy to identify target genes that are synthetic lethal (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83050179cf93c1b4da465cfabd469fb6
https://doi.org/10.1101/588707
https://doi.org/10.1101/588707
Autor:
David Hermanson, Jignesh M. Doshi, Sadiya N. Addo, Sonia G. Das, Balasubramanian Srinivasan, Defeng Tian, Chengguo Xing
Publikováno v:
Journal of Medicinal Chemistry. 52:5937-5949
Rapid development of multiple drug resistance against current therapies is a major barrier in the treatment of cancer. Therefore, anticancer agents that can overcome acquired drug resistance in cancer cells are of great importance. Previously, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a08fddb26a139e80d78855f8624563
https://doi.org/10.1021/jm9005059
https://doi.org/10.1021/jm9005059
Autor:
Sonia G. Das, Balasubramanian Srinivasan, Chengguo Xing, Fawaz Al-Mousa, Sadiya N. Addo, Tucker W. LeBien, Francesco Michelangeli, David D. Thomas, David Hermanson, Anna A. Bajer, Jonathan S. Marchant
Publikováno v:
Molecular Pharmacology. 76:667-678
HA 14-1 is a small-molecule Bcl-2 antagonist that promotes apoptosis in malignant cells, but its mechanism of action is not well defined. We recently reported that HA 14-1 has a half-life of only 15 min in vitro, which led us to develop a stable anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6077db981244b62810221d2fdfb866d
https://doi.org/10.1124/mol.109.055830
https://doi.org/10.1124/mol.109.055830
Autor:
Joel W. Slaton, Defeng Tian, Sadiya N. Addo, Liangyou Wang, Dan Sloper, Chengguo Xing, Ryoko Kuriyama
Publikováno v:
Journal of Urology. 179:225-226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca452d61b1d34c31b8a81aaeac0a2e5
https://doi.org/10.1016/s0022-5347(08)60650-3
https://doi.org/10.1016/s0022-5347(08)60650-3
Autor:
Sonia G. Das, Jignesh M. Doshi, Defeng Tian, Sadiya N. Addo, Balasubramanian Srinivasan, David L. Hermanson, Chengguo Xing
Publikováno v:
Journal of Medicinal Chemistry; Oct2009, Vol. 52 Issue 19, p5937-5949, 13p