Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sadiya Malik"'
Publikováno v:
Cell Cycle
BRCA2 is responsible for familial breast and ovarian cancer and has been linked to DNA repair and centrosome duplication. Here we analyzed the mechanism by which the centrosomal localization signal (CLS) of BRCA2 interacts with cytoplasmic dynein 1 t
Autor:
Yoshio Miki, Kana Hosokawa, Nadila Wali, Sadiya Malik, Shinobu Imajoh-Ohmi, Hiroko Saito, Ken Miyaguchi, Akira Nakanishi
Publikováno v:
Biochemical and Biophysical Research Communications. 443:1148-1154
BRCA2 localizes to centrosomes between G1 and prophase and is removed from the centrosomes during mitosis, but the underlying mechanism is not clear. Here we show that BRCA2 is cleaved into two fragments by membrane type-1 matrix metalloproteinase (M