Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sadim, Jawhar"'
1
Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease
Autor: Anja Harmeier, Sathish Kumar, Lars Lannfelt, Christian Erck, Henrik Martens, Oliver Wirths, Constanze Geumann, Gerd Multhaup, Sadim Jawhar, Hannu Kalimo, Martin Ingelsson, Thomas A. Bayer, Jochen Walter, Inge Huitinga, Malin Degerman-Gunnarsson
Publikováno v: Journal of Biological Chemistry. 285:41517-41524
N-terminally truncated Aβ peptides starting with pyroglutamate (AβpE3) represent a major fraction of all Aβ peptides in the brain of Alzheimer disease (AD) patients. AβpE3 has a higher aggregation propensity and stability and shows increased toxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c679dbe6880b8de821fe19b194b7e8d
https://doi.org/10.1074/jbc.m110.178707
Zobrazit plný text záznamu
2
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases
Autor: Gerd Multhaup, Oliver Wirths, Andrea Marcello, Tobias Bethge, Thomas A. Bayer, Thomas J. Esparza, Martin Ingelsson, Sadim Jawhar, Hannu Kalimo, Paul J. Lucassen, Lars Lannfelt, Anja Harmeier, David L. Brody
Publikováno v: Journal of Neural Transmission, 117(1), 85-96. Springer Verlag
Journal of Neural Transmission
The presence of A beta(pE3) (N-terminal truncated A beta starting with pyroglutamate) in Alzheimer's disease (AD) has received considerable attention since the discovery that this peptide represents a dominant fraction of A beta peptides in senile pl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94cd4574ef38a90c3916b6953b95f6c
https://dare.uva.nl/personal/pure/en/publications/pyroglutamate-abeta-pathology-in-appps1ki-mice-sporadic-and-familial-alzheimers-disease-cases(d8c19315-ef9f-4b55-8664-70b07b24d878).html
Zobrazit plný text záznamu
4
Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease*
Autor: Oliver Wirths, Sadim Jawhar, Thomas A. Bayer
Pyroglutamate-modified amyloid-β (Aβ(pE3)) peptides are gaining considerable attention as potential key participants in the pathology of Alzheimer disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de61a19f61cd67933e68039d07d990fe
https://europepmc.org/articles/PMC3234707/
Zobrazit plný text záznamu
6
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice
Autor: Stephan Schilling, Sigrid Graubner, Sadim Jawhar, Thomas A. Bayer, Oliver Wirths, Hans-Ulrich Demuth
Publikováno v: The Journal of biological chemistry. 286(6)
Pyroglutamate-modified Aβ (AβpE3–42) peptides are gaining considerable attention as potential key players in the pathology of Alzheimer disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff4abcefc9acde5761616ae73826176
https://pubmed.ncbi.nlm.nih.gov/21148560
Zobrazit plný text záznamu
7
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis
Autor: Oliver, Wirths, Christian, Erck, Henrik, Martens, Anja, Harmeier, Constanze, Geumann, Sadim, Jawhar, Sathish, Kumar, Gerd, Multhaup, Jochen, Walter, Martin, Ingelsson, Malin, Degerman-Gunnarsson, Hannu, Kalimo, Inge, Huitinga, Lars, Lannfelt, Thomas A, Bayer
Publikováno v: The Journal of biological chemistry. 285(53)
N-terminally truncated Aβ peptides starting with pyroglutamate (AβpE3) represent a major fraction of all Aβ peptides in the brain of Alzheimer disease (AD) patients. AβpE3 has a higher aggregation propensity and stability and shows increased toxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6a861d1d28cc57d88b63f59362b4bc1
https://pubmed.ncbi.nlm.nih.gov/20971852
Zobrazit plný text záznamu
8
Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
Autor: Ditte Z. Christensen, Marie-Caroline Cotel, Thomas A. Bayer, Oliver Wirths, Sadim Jawhar
Publikováno v: Neurobiology of aging. 33(1)
Environmental enrichment has been used in a variety of transgenic mouse models of Alzheimer's disease (AD), however, with conflicting results. Here we studied the influence of environmental enrichment in a severely affected AD mouse model, showing a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b894bb7d50cf8b84f95c537a296270a2
https://pubmed.ncbi.nlm.nih.gov/20359774
Zobrazit plný text záznamu
9
Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
Autor: Thomas A. Bayer, Carolin Jenneckens, Oliver Wirths, Sadim Jawhar, Anna Trawicka
Publikováno v: Neurobiology of Aging. 33:196.e29-196.e40
In the present report, we extend previous findings in the 5XFAD mouse model and demonstrate that these mice develop an age-dependent motor phenotype in addition to working memory deficits and reduced anxiety levels as demonstrated in an elevated plus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9362e1261338c5c9b373d2ae4c75801
https://doi.org/10.1016/j.neurobiolaging.2010.05.027
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje