Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways.

Autor: Hamidzada H; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON.; Department of Immunology, University of Toronto, Toronto, ON., Pascual-Gil S; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON., Wu Q; Institute of Biomedical Engineering, University of Toronto, Toronto, ON., Kent GM; McEwen Stem Cell Institute, University Health Network, Toronto, ON.; Department of Medical Biophysics, University of Toronto, Toronto, ON., Massé S; The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON., Kantores C; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON., Kuzmanov U; Department of Physiology, University of Toronto, Toronto, ON., Gomez-Garcia MJ; Institute of Biomedical Engineering, University of Toronto, Toronto, ON.; McEwen Stem Cell Institute, University Health Network, Toronto, ON., Rafatian N; Institute of Biomedical Engineering, University of Toronto, Toronto, ON., Gorman RA; Department of Biology, York University, Toronto, ON., Wauchop M; Department of Biology, York University, Toronto, ON., Chen W; Scientific Research Center, the Second Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, 524023, China., Landau S; Institute of Biomedical Engineering, University of Toronto, Toronto, ON., Subha T; The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON., Atkins MH; McEwen Stem Cell Institute, University Health Network, Toronto, ON.; Department of Medical Biophysics, University of Toronto, Toronto, ON., Zhao Y; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON., Beroncal E; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON., Fernandes I; McEwen Stem Cell Institute, University Health Network, Toronto, ON.; Department of Medical Biophysics, University of Toronto, Toronto, ON., Nanthakumar J; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON., Vohra S; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON., Wang EY; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, United States., Sadikov TV; McEwen Stem Cell Institute, University Health Network, Toronto, ON., Razani B; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, United States.; Department of Cardiology, Pittsburgh VA Medical Center, Pittsburgh, PA, United States., McGaha TL; Department of Immunology, University of Toronto, Toronto, ON.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON., Andreazza AC; Department of Psychiatry, University of Toronto, Toronto, ON.; Mitochondrial Innovation Initiative, Toronto, ON., Gramolini A; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON.; Department of Physiology, University of Toronto, Toronto, ON., Backx PH; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Department of Physiology, University of Toronto, Toronto, ON.; Department of Biology, York University, Toronto, ON., Nanthakumar K; The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, ON., Laflamme MA; McEwen Stem Cell Institute, University Health Network, Toronto, ON.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON., Keller G; McEwen Stem Cell Institute, University Health Network, Toronto, ON.; Department of Medical Biophysics, University of Toronto, Toronto, ON.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON., Radisic M; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON.; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, ON., Epelman S; Toronto General Hospital Research Institute, University Health Network, Toronto, ON.; Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON.; Department of Immunology, University of Toronto, Toronto, ON.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 May; Vol. 3 (5), pp. 567-593. Date of Electronic Publication: 2024 May 07.