Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sadik Oner"'
Autor:
Sebiha Cevik, Xiaoyu Peng, Tina Beyer, Mustafa S Pir, Ferhan Yenisert, Franziska Woerz, Felix Hoffmann, Betul Altunkaynak, Betul Pir, Karsten Boldt, Asli Karaman, Miray Cakiroglu, S Sadik Oner, Ying Cao, Marius Ueffing, Oktay I Kaplan
Publikováno v:
Life Science Alliance. 6:e202201844
The correct intraflagellar transport (IFT) assembly at the ciliary base and the IFT turnaround at the ciliary tip are key for the IFT to perform its function, but we still have poor understanding about how these processes are regulated. Here, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e80889987b851cd5a4c9feb2e05fb58
https://doi.org/10.26508/lsa.202201844
https://doi.org/10.26508/lsa.202201844
Autor:
Sadik Oner, Betul Pir, Felix Hoffmann, Betul Altunkaynak, Karsten Boldt, Xiaoyu Peng, Fowzan S. Alkuraya, Sebiha Cevik, Ying Cao, Asli Karaman, Lama Al-Abdi, Marius Ueffing, Franziska Woerz, Ferhan Yenisert, Ranad Shaheen, Miray Cakiroglu, Mustafa S. Pir, Atiyye Zorluer, Oktay I. Kaplan, Tina Beyer
The term “ciliopathy” refers to a group of over 35 rare disorders characterized by defective cilia and many overlapping clinical features, such as hydrocephalus, cerebellar vermis hypoplasia, polydactyly, and retinopathy. Even though many genes h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a6f3e4894f80172c7bc15dca3f1880
https://doi.org/10.21203/rs.3.rs-622797/v1
https://doi.org/10.21203/rs.3.rs-622797/v1
Autor:
Sebiha Cevik, Xiaoyu Peng, Tina Beyer, Mustafa S. Pir, Ferhan Yenisert, Franziska Woerz, Felix Hoffmann, Betul Altunkaynak, Betul Pir, Karsten Boldt, Asli Karaman, Miray Cakiroglu, S. Sadik Oner, Ying Cao, Marius Ueffing, Oktay I. Kaplan
The correct intraflagellar transport (IFT) assembly at the ciliary base and the IFT turnaround at the ciliary tip are key for the IFT to perform its function, but we still have poor understanding about how these processes are regulated. Here, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86fe6053f280e181442b5b918d90bac4
https://doi.org/10.1101/2021.06.10.445528
https://doi.org/10.1101/2021.06.10.445528
Publikováno v:
Molecular Pharmacology. 88:231-237
Group II activator of G-protein signaling (AGS) proteins contain one or more G-protein regulatory motifs (GPR), which serve as docking sites for GαiGDP independent of Gβγ and stabilize the GDP-bound conformation of Gαi, acting as guanine nucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccb0840fb9f786fe2400cf84b1b9d17
https://doi.org/10.1124/mol.115.097741
https://doi.org/10.1124/mol.115.097741
Publikováno v:
Molecular Pharmacology. 82:17-26
The proto-oncogene and inhibitor of protein phosphatase 2A (PP2A), SET, interacts with the third intracellular loop of the M3 muscarinic receptor (M3-MR), and SET knockdown with small interfering RNA (siRNA) in Chinese hamster ovary (CHO) cells augme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30d53c4c79ac0bc31e2310565702c0b
https://doi.org/10.1124/mol.111.075523
https://doi.org/10.1124/mol.111.075523
Publikováno v:
Acta Physiologica. 204:202-218
Beyond the core triad of receptor, Gαβγ and effector, there are multiple accessory proteins that provide alternative modes of signal input and regulatory adaptability to G-protein signalling systems. Such accessory proteins may segregate a signall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db472111a5a26d22c5111f7065862a04
https://doi.org/10.1111/j.1748-1716.2011.02327.x
https://doi.org/10.1111/j.1748-1716.2011.02327.x
Autor:
PuiYee Chan, Wei Kan, Forrest A. Wright, Alan V. Smrcka, Meital Gabay, Joe B. Blumer, Sukru Sadik Oner, Gregory G. Tall, Stephen M. Lanier
Publikováno v:
Journal of Biological Chemistry. 286:2625-2635
Ric-8A and Ric-8B are nonreceptor G protein guanine nucleotide exchange factors that collectively bind the four subfamilies of G protein α subunits. Co-expression of Gα subunits with Ric-8A or Ric-8B in HEK293 cells or insect cells greatly promoted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ea04d9476d016356c0b9cd8460a87b
https://doi.org/10.1074/jbc.m110.178897
https://doi.org/10.1074/jbc.m110.178897
Autor:
Sukru Sadik Oner, Joe B. Blumer, Ningfei An, Ali Vural, Stephen M. Lanier, Billy Breton, Michel Bouvier
Publikováno v:
Journal of Biological Chemistry. 285:33949-33958
G-protein signaling modulators (GPSM) play diverse functional roles through their interaction with G-protein subunits. AGS3 (GPSM1) contains four G-protein regulatory motifs (GPR) that directly bind Gα(i) free of Gβγ providing an unusual scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2999a4bf4745d24a3261ed454658375f
https://doi.org/10.1074/jbc.m110.138073
https://doi.org/10.1074/jbc.m110.138073
Autor:
Violaine Simon, Ningfei An, Joe B. Blumer, Stephen M. Lanier, Ali Vural, Dzwokai Ma, Sadik Oner
Publikováno v:
Molecular and Cellular Biology. 30:1528-1540
AGS3, a receptor-independent activator of G-protein signaling, is involved in unexpected functional diversity for G-protein signaling systems. AGS3 has seven tetratricopeptide (TPR) motifs upstream of four G-protein regulatory (GPR) motifs that serve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e45ab9c0ec074161474140f8d11d4b4
https://doi.org/10.1128/mcb.01018-09
https://doi.org/10.1128/mcb.01018-09
Group II activators of G-protein signaling play diverse functional roles through their interaction with Gαi, Gαt, and Gαo via a G-protein regulatory (GPR) motif that serves as a docking site for Gα-GDP. We recently reported the regulation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d652f2bffb0d840d73a2619561c4f3be
https://europepmc.org/articles/PMC3745352/
https://europepmc.org/articles/PMC3745352/