Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sadik H. Kassim"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101170- (2024)
Cell and gene therapies (CGTs) have revolutionized patient outcomes and provided care options for previously untreatable conditions. The clinical and commercial progress of CGT therapies is hindered by chemistry, manufacturing, and control (CMC) chal
Externí odkaz:
https://doaj.org/article/8e9b13b3f30b4498a088427af91fdfe2
Autor:
Qiong Xue, Emily Bettini, Patrick Paczkowski, Colin Ng, Alaina Kaiser, Timothy McConnell, Olja Kodrasi, Máire F. Quigley, James Heath, Rong Fan, Sean Mackay, Mark E. Dudley, Sadik H. Kassim, Jing Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract Background It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in pati
Externí odkaz:
https://doaj.org/article/ad391b0cd0634de0af9c0fb1b8b1b2e4
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Supplementary Figure 1 and 2. Supplementary Figure 1. Evaluation of persistence and function of TCR-transduced T cells following adoptive transfer in responding and non-responding patients. Supplementary Figure 2. Evaluation of function of TCR-transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc1cf8ba70860c58ddf599782c76223
https://doi.org/10.1158/1078-0432.22460966.v1
https://doi.org/10.1158/1078-0432.22460966.v1
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
Supplemental figure 2. Phenotype of NFAT.IL12 gene modified TIL compared to matched untransduced TIL.Shown are the percentage of cells with a phenotype consistent with effector memory (CD62L-CD45RA-),central memory (CD62L+CD45RA-), Naive (CD62+, CD45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b62ad53dd29f0fe028259344ccc6ef
https://doi.org/10.1158/1078-0432.22457129.v1
https://doi.org/10.1158/1078-0432.22457129.v1
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Purpose: Although adoptive cell therapy can be highly effective for the treatment of patients with melanoma, the application of this approach to the treatment of other solid tumors has been limited. The observation that the cancer germline (CG) antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a85db2fc034bced91a4aed33233ba
https://doi.org/10.1158/1078-0432.c.6524657.v1
https://doi.org/10.1158/1078-0432.c.6524657.v1
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Legends for Supplementary Figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368914cc972a3a957a3c1494e3df97e9
https://doi.org/10.1158/1078-0432.22460963.v1
https://doi.org/10.1158/1078-0432.22460963.v1
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
Supplemental figure 4. IL6 and IL10 levels. Shown are data from five patients with elevated IL12 and IFNg levels that were subject to cytokine multiplex analysis. Only cytokine IL6 and IL10 were shown to be consistently elevated post-infusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e695baf815b4bc7224d3617847ff746
https://doi.org/10.1158/1078-0432.22457123.v1
https://doi.org/10.1158/1078-0432.22457123.v1
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
supplemental figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d52a157271b8a79321afb83b58df0d
https://doi.org/10.1158/1078-0432.22457117
https://doi.org/10.1158/1078-0432.22457117
Autor:
Steven A. Rosenberg, Mona El-Gamil, Yong F. Li, Chyi-Chia R. Lee, Mark Raffeld, Nicholas P. Restifo, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, John R. Wunderlich, Mark E. Dudley, James C. Yang, Steven A. Feldman, Richard A. Morgan, Jessica S. Crystal, Thai L.N. Tran, Sadik H. Kassim, Paul F. Robbins
Supplementary Table 1. Melanoma patients: Prior treatments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09421af460dae8f11bf49d28715662bf
https://doi.org/10.1158/1078-0432.22460960
https://doi.org/10.1158/1078-0432.22460960
Autor:
Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo, Sid P. Kerkar, Mary Ann Toomey, Steven A. Feldman, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Richard M. Sherry, Lien T. Ngo, Azam V. Nahvi, Sadik H. Kassim, Mark E. Dudley, Zhili Zheng, Joal D. Beane, Richard A. Morgan, Ling Zhang
Supplemental figure 5. Treg reconstitution. Shown are the percentages of circulating T cells with a phenotype consistent with a Treg cell (CD4+/CD25+/FoxP3+). Data from parallel TIL trial using TIL administration but without exogenous IL2 support (TI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b749df4850268d6b252d83408150c20
https://doi.org/10.1158/1078-0432.22457120.v1
https://doi.org/10.1158/1078-0432.22457120.v1