Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis

Autor: Seungwoo Chang, Elizabeth S. Thrall, Luisa Laureti, Sadie C. Piatt, Vincent Pagès, Joseph J. Loparo

Publikováno v: Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 2022, 29 (9), pp.932+. ⟨10.1038/s41594-022-00827-2⟩
Nat Struct Mol Biol

Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer-template junction. In addition to DNA replication, DNA polymerases also participate in various genome maintenance activities, including translesion synthesis (TLS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a976ee7bf300c9759acd8812d70dfd9a
https://doi.org/10.1038/s41594-022-00827-2

XLF acts as a flexible connector during non-homologous end joining

Autor: Felicia Wednesday Lopezcolorado, Joseph J. Loparo, Sean M. Carney, Metztli Cisneros-Aguirre, Sadie C. Piatt, Jeremy M. Stark, Andrew T. Moreno

Publikováno v: eLife, Vol 9 (2020)
eLife

Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks in vertebrates. During NHEJ DNA ends are held together by a multi-protein synaptic complex until they are ligated. Here, we use Xenopus laevis egg extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963aadcff0373bd86bc42a6ec4ff4840
https://doi.org/10.7554/elife.61920

Quantifying the Contribution of Habitats and Pathways to a Spatially Structured Population Facing Environmental Change

Autor: Alyssa Carson, Connor Higgins, Brady J. Mattsson, James E. Diffendorfer, Benjamin L. Allen, Christine Sample, Wayne E. Thogmartin, Joanna A. Bieri, Sadie C. Piatt, Darius J. Semmens, Shirley Qiu, Yulia Dementieva, Summer Stafford

Publikováno v: The American naturalist. 196(2)

The consequences of environmental disturbance and management are difficult to quantify for spatially structured populations because changes in one location carry through to other areas as a result of species movement. We develop a metric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d027109d154358d950db1909880c14c3
https://pubmed.ncbi.nlm.nih.gov/32673098

The sequence dependent search mechanism of EcoRI

Autor: Joseph J. Loparo, Sadie C. Piatt, Allen C. Price

One-dimensional search is an essential step in DNA target recognition. Theoretical studies have suggested that the sequence dependence of one-dimensional diffusion can help resolve the competing demands of fast search and high target affinity, a conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7deb3063114af222dc3b235410d49a2
https://doi.org/10.1101/444042

Quantifying source and sink habitats and pathways in spatially structured populations: A generalized modelling approach

Autor: Summer Stafford, Joanna A. Bieri, Brady J. Mattsson, Benjamin L. Allen, Sadie C. Piatt, Alyssa Carson, Christine Sample, Jay E. Diffendorfer, Connor Higgins, Darius J. Semmens, Wayne E. Thogmartin, Yulia Dementieva, Shirley Qiu

Publikováno v: Ecological Modelling. 407:108715

The ability to classify habitats and movement pathways as sources or sinks is an important part of the decision making process for the conservation of spatially structured populations. Diverse approaches have been used to quantify the importance of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c42a2459afc047d62fda39805ac4322b
https://doi.org/10.1016/j.ecolmodel.2019.06.003