Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sadegh Saghafinia"'
Autor:
Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375
Externí odkaz:
https://doaj.org/article/72661e3a38244d87bdf71ce5806af456
Autor:
Elizabeth Allen, Pascal Miéville, Carmen M. Warren, Sadegh Saghafinia, Leanne Li, Mei-Wen Peng, Douglas Hanahan
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1144-1160 (2016)
Therapeutic targeting of tumor angiogenesis with VEGF inhibitors results in demonstrable, but transitory efficacy in certain human tumors and mouse models of cancer, limited by unconventional forms of adaptive/evasive resistance. In one such mouse mo
Externí odkaz:
https://doaj.org/article/4bbbbb0865f4495b858a449ab70a0dd5
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1066-1080.e8 (2018)
Summary: The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET
Externí odkaz:
https://doaj.org/article/bf05db057e0047f3a6c38a0dd4c57502
Autor:
Douglas Hanahan, Iacovos P. Michael, Giovanni Ciriello, Ilaria Marinoni, Aurel Perren, Stephan Wullschleger, Annunziata Di Domenico, Krisztian Homicsko, Sadegh Saghafinia
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80e2b780884e07e45ed59968e2430a0
https://doi.org/10.1158/2159-8290.22539799
https://doi.org/10.1158/2159-8290.22539799
Autor:
Douglas Hanahan, Iacovos P. Michael, Giovanni Ciriello, Ilaria Marinoni, Aurel Perren, Stephan Wullschleger, Annunziata Di Domenico, Krisztian Homicsko, Sadegh Saghafinia
Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the origin of aggressive MLP tumors has been obscure. Herein, using multi-om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55928165aa56575e368984fc1bba348
https://doi.org/10.1158/2159-8290.c.6549190.v1
https://doi.org/10.1158/2159-8290.c.6549190.v1
Autor:
Douglas Hanahan, Iacovos P. Michael, Giovanni Ciriello, Ilaria Marinoni, Aurel Perren, Stephan Wullschleger, Annunziata Di Domenico, Krisztian Homicsko, Sadegh Saghafinia
Supplementary Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9338d68d5085ad3a5d6b752e40167f
https://doi.org/10.1158/2159-8290.22539805.v1
https://doi.org/10.1158/2159-8290.22539805.v1
Autor:
Qiqun Zeng, Sadegh Saghafinia, Agnieszka Chryplewicz, Nadine Fournier, Lucine Christe, Yu-Qing Xie, Jeremy Guillot, Simge Yucel, Pumin Li, José A. Galván, Eva Karamitopoulou, Inti Zlobec, Dalya Ataca, Fleuriane Gallean, Peng Zhang, José Antonio Rodriguez-Calero, Mark Rubin, Mélanie Tichet, Krisztian Homicsko, Douglas Hanahan
Publikováno v:
Science (New York, N.Y.). 378(6621)
Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The capabilities for invasion and metastasis underlie the mortality and morbidity of most forms of human cancer. Currently, there are no effective therapies specifically targeting these cancer phenotypes, in part due to the paucity of do
Autor:
Brian D. McCabe, Douglas Hanahan, Graham Knott, Qiqun Zeng, Sadegh Saghafinia, Giovanni Ciriello, Peng Zhang, Inti Zlobec, Hugh P. C. Robinson, Wei Jiao, José A. Galván, Iacovos P. Michael
Publikováno v:
Nature, vol. 573, no. 7775, pp. 526-531
Nature
Nature
Summary Metastasis - the disseminated growth of tumours in distant organs – underlies cancer mortality. Breast-to-brain metastasis (B2BM) is disconcertingly common and disruptive, being prevalent in the aggressive basal-like subtype, albeit evident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19da7ac88268bc4a40f18131aa355b84
https://serval.unil.ch/notice/serval:BIB_7FA9C67632A4
https://serval.unil.ch/notice/serval:BIB_7FA9C67632A4
Tumour cells mirror embryonic developmental programs to acquire invasive and metastatic capabilities
Publikováno v:
Annals of Oncology. 30:vii2
Background Pancreatic Neuroendocrine Tumours (PanNETs) are the second most common form of pancreatic cancer. We previously identified two principal subtypes of PanNET: insulinomas (islet tumors; IT) and metastasis-like primaries (MLP), corresponding