Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Sadeesh K. Ramakrishnan"'
Autor:
Raja Gopal Reddy Mooli, Bokai Zhu, Saifur R. Khan, Veerababu Nagati, Kulandaimanuvel Antony Michealraj, Michael J. Jurczak, Sadeesh K. Ramakrishnan
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundThermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic and contribute to >50% of beige adipocytes in adults. Neonatal beige adipo
Externí odkaz:
https://doaj.org/article/c67b53bffb8a42d4b4b60b741db8cbda
Autor:
Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne Orr, Siddhi Jain, Shirish Paranjpe, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, Joseph Locker, Wendy M. Mars, George K. Michalopoulos, Bharat Bhushan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 4, Pp 101380- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB inhibitor, Canertinib, in
Externí odkaz:
https://doaj.org/article/f29f693fd932476384c13a2ebe3c29a5
Autor:
Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1057-1072 (2022)
Background & Aims: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circ
Externí odkaz:
https://doaj.org/article/02b6ec9b78e94fa7a0450ec4181773fa
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as triglycerides. Although NAFL is benign, it could progress to non-alcoholic s
Externí odkaz:
https://doaj.org/article/b5e00e67df024e619eb775e0d84b1b7e
Autor:
Raja Gopal Reddy Mooli, Jessica Rodriguez, Shogo Takahashi, Sumeet Solanki, Frank J. Gonzalez, Sadeesh K. Ramakrishnan, Yatrik M. Shah
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 585-597 (2021)
Background & Aims: Fatty liver or nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with comorbidities such as insulin resistance and cardiovascular and metabolic diseases. Chronic activation of hypoxic signaling, i
Externí odkaz:
https://doaj.org/article/ddbf79f26014419cb7dcf2170ec703f9
Autor:
Yikai Shao, Simon S. Evers, Jae Hoon Shin, Sadeesh K. Ramakrishnan, Nadejda Bozadjieva-Kramer, Qiyuan Yao, Yatrik M. Shah, Darleen A. Sandoval, Randy J. Seeley
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101432- (2022)
Objective: Vertical Sleeve Gastrectomy (VSG) is one of the most efficacious treatments for obesity and its comorbidities. Although a range of evidence suggests that alterations of the microbiota in the distal gut following VSG are pivotal to these me
Externí odkaz:
https://doaj.org/article/831fd8d516454b6b8a5e46bb1c32d9d3
Autor:
Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet co
Externí odkaz:
https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1
Autor:
Lisa Y. Beppu, Raja Gopal Reddy Mooli, Xiaoyao Qu, Giovanni J. Marrero, Christopher A. Finley, Allen N. Fooks, Zachary P. Mullen, Adolfo B. Frias Jr., Ian Sipula, Bingxian Xie, Katherine E. Helfrich, Simon C. Watkins, Amanda C. Poholek, Sadeesh K. Ramakrishnan, Michael J. Jurczak, Louise M. D’Cruz
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress inflammation. Paradoxically, immune cell–derived IL-10 can drive insulin resistance in obesity by suppressing adipocyte energy expenditure and thermogenesis. However, th
Externí odkaz:
https://doaj.org/article/9126b15b09d845f0ae956d6a926c8723
Autor:
Heather K. Schofield, Manuj Tandon, Min-Jung Park, Christopher J. Halbrook, Sadeesh K. Ramakrishnan, Esther C. Kim, Jiaqi Shi, M. Bishr Omary, Yatrik M. Shah, Farzad Esni, Marina Pasca di Magliano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 2, Pp 169-185.e2 (2018)
Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies
Externí odkaz:
https://doaj.org/article/53f16139687c433192293bdf2c388f4a
Autor:
Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi K. Kaw, Harrison T. Muturi, Sumona Ghosh Lester, Sang Jun Lee, Larisa V. Fedorova, Andrea J. Kim, Iman E. Mohamed, Cara Gatto-Weis, Kathryn M. Eisenmann, Philip B. Conran, Sonia M. Najjar
Publikováno v:
Molecular Metabolism, Vol 4, Iss 3, Pp 186-198 (2015)
Objective: Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low prostatic intraepithelial neoplas
Externí odkaz:
https://doaj.org/article/24214b1274ba4cadbbe959f675aed991