Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sadayappan V. Rahavendran"'
Autor:
Shaoxian Sun, Phuong Le, Shubha Bagrodia, Sadayappan V. Rahavendran, Eric Zhang, Cheng Hengmiao, Cathy Xiang, Robert Steven Kania, Jing Yuan, William Farrell, Jacqui Elizabeth Hoffman, Pairish Mason Alan, Deepak Dalvie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2787-2792
PI3K, AKT and mTOR, key kinases from a frequently dysregulated PI3K signaling pathway, have been extensively pursued to treat a variety of cancers in oncology. Clinical trials of PF-04691502, a highly potent and selective ATP competitive kinase inhib
Publikováno v:
Journal of Chromatography B. 879:2860-2865
In the oncology therapeutic area, the mouse is the primary animal model used for efficacy studies. Often with mouse pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD) studies, less than 20 μL of total plasma sample volume is available
Autor:
Sadayappan V. Rahavendran, Zhongzhou Shen, Cory L. Painter, Wei-Zhu Zhong, Leslie Nguyen, Cathy Zhang
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 53:228-234
Phase II attrition of clinical candidates in the drug development cycle is currently a major issue facing the pharmaceutical industry. To decrease phase II attrition, there is an increased emphasis on validation of mechanism of action, development of
Autor:
Melvin Toh, Matthew Green, Yazdi K. Pithavala, Thomas Marbury, Robert R. LaBadie, Christine Alvey, Grace Ni, Sadayappan V. Rahavendran, Michael A. Tortorici, Brian Hee, Ernesto Fuentes
Publikováno v:
Investigational New Drugs
Summary Objective: To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single, oral axitinib dose in subjects with mild or moderate hepatic impairment. Methods: In this phase I, open-label, parallel-group study, a to
Autor:
Qinghai Peng, Nowlin Dawn Marie, Hieu Lam, Ted William Johnson, Yang Anle, Wen Liu, Atsuo Kuki, Steven P. Tanis, Jon E. Kuehler, Zhang Junhu, Hai Wang, Plewe Michael Bruno, Scott L. Butler, Tran Khanh Tuan, Qiyue Hu, Sadayappan V. Rahavendran, Klaus Ruprecht Dress
Publikováno v:
Journal of Medicinal Chemistry. 52:7211-7219
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxyli
Autor:
Susan Binford, Heather Skor, Angelica Linton, Sadayappan V. Rahavendran, Stephanie T. Shi, Amy K. Patick, Javier Gonzalez, Jim Nonomiya, Hui Li, Koleen J. Herlihy, Rebecca Irvine, Joanne P. Graham, Tatlock John H, Cristina Lewis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2544-2552
PF-00868554 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, which exerts its inhibitory effect by binding to the thumb base domain of the protein. It is a potent and selective inhibitor, with a mean 50% inhibitory concentr
Autor:
Javier Gonzalez, Jim Nonomiya, Angelica Linton, Leena Patel, Hui Li, Fannie Chau, Hans E. Parge, Sadayappan V. Rahavendran, Heather Skor, Michael J. Hickey, Tanya Michelle Jewell, Matthew Drowns, Stephanie T. Shi, Robert P. Hunter, Cristina Lewis, Sarah Ludlum, Tatlock John H, Koleen J. Herlihy, Xiu Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:1255-1258
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhi
Publikováno v:
Instrumentation Science & Technology. 25:121-131
An HPLC - visible diode laser induced fluorescence detector (VDLIF) has been constructed and its performance evaluated using nile blue, a far red oxazine reagent. The divergent output beam of the diode laser was collimated to an elliptical shaped bea
Publikováno v:
Analytica Chimica Acta. 342:145-149
Diode laser induced near infra-red fluorescence (DLINIRF) detection has become important in bioanalysis due to the increased sensitivity and selectivity that can be achieved in biological matrices as well as the ruggedness, low cost, stability and po
Publikováno v:
Handbook of LC-MS Bioanalysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef80393a5d4c30e635323c6a3e1a5235
https://doi.org/10.1002/9781118671276.ch50
https://doi.org/10.1002/9781118671276.ch50