Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sadatsugu Sakane"'
Autor:
Hyun Young Kim, Wonseok Lee, Xiao Liu, Haeum Jang, Sadatsugu Sakane, Raquel Carvalho-Gontijo Weber, Karin Diggle, Samuel A. Kerk, Christian M. Metallo, Tatiana Kisseleva, David A. Brenner
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103111- (2024)
Summary: Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human liver spheroids that contain all the live
Externí odkaz:
https://doaj.org/article/4d3e50db289e472d86f78e55cfae2e45
Autor:
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 93-106 (2024)
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is c
Externí odkaz:
https://doaj.org/article/0f9a90d94d5e4bd0a2e4ea88044b0319
Autor:
Natalia A. Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim, Wonseok Lee, Souradipta Ganguly, Yusuke Kimura, Xiao Liu, Debanjan Dhar, Karin Diggle, David A. Brenner, Tatiana Kisseleva, Neha Attal, Iain H. McKillop, Shilpa Chokshi, Ram Mahato, Karuna Rasineni, Gyongyi Szabo, Kusum K. Kharbanda
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 404 (2024)
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Mult
Externí odkaz:
https://doaj.org/article/142e2cdd280940af8c937a0c17615d54
Autor:
Xiao Liu, Kevin Lam, Huayi Zhao, Sadatsugu Sakane, Hyun Young Kim, Alvaro Eguileor, Karin Diggle, Shuai Wu, Raquel Carvalho Gontijo Weber, Pejman Soroosh, Mojgan Hosseini, Kristin Mekeel, David A. Brenner, Tatiana Kisseleva
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102391- (2023)
Summary: Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and optimization of chemical dige
Externí odkaz:
https://doaj.org/article/06a0220e8c7f4637ab4455a2add3b85d
Autor:
Yuki Makino, Hayato Hikita, Seiya Kato, Masaya Sugiyama, Minoru Shigekawa, Tatsuya Sakamoto, Yoichi Sasaki, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Hidetoshi Eguchi, Nobuyuki Takemura, Norihiro Kokudo, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 99-119 (2023)
Background & Aims: Signal transducer and activator of transcription 3 (STAT3) is known as a pro-oncogenic transcription factor. Regarding liver carcinogenesis, however, it remains controversial whether activated STAT3 is pro- or anti-tumorigenic. Thi
Externí odkaz:
https://doaj.org/article/1eb3d8992b60484ab06969f6bb67f258
Autor:
Makiko Urabe, Hayato Hikita, Yoshinobu Saito, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuta Myojin, Akira Doi, Katsuhiko Sato, Sadatsugu Sakane, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 411-422 (2022)
Radiation therapy is one of the treatment methods for hepatocellular carcinoma. However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified. C57BL/6J mice or hepatocyte‐specifi
Externí odkaz:
https://doaj.org/article/5d2950503bef4743843441edf7653b78
Autor:
Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Kenji Fukumoto, Makiko Urabe, Katsuhiko Sato, Yuta Myojin, Akira Doi, Kazuhiro Murai, Sadatsugu Sakane, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Hepatocellular carcinoma highly occurs in chronic hepatitis livers, where hepatocyte apoptosis is frequently detected. Apoptosis is a mechanism that eliminates mutated cells. Hepatocyte apoptosis induces compensatory liver regeneration, whic
Externí odkaz:
https://doaj.org/article/7a3c1eb510344afeaca4f3f59650deab
Autor:
Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1683-1699 (2021)
Background & Aims: Although nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity, the role of adipose tissue in NAFLD is not well-understood. Because autophagy has been reported to be involved in the degradation of lipid drople
Externí odkaz:
https://doaj.org/article/6c57edd099aa446b96cd53391b486ebb
Autor:
Kumiko Shirai, Hayato Hikita, Ryotaro Sakamori, Akira Doi, Yuki Tahata, Sadatsugu Sakane, Yoshihiro Kamada, Kazuhiro Murai, Akira Nishio, Ryoko Yamada, Takahiro Kodama, Yasutoshi Nozaki, Naruyasu Kakita, Hisashi Ishida, Fumihiko Nakanishi, Naoki Morishita, Kazuho Imanaka, Mitsuru Sakakibara, Tomohide Tatsumi, Eiji Miyoshi, Tetsuo Takehara
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279416 (2022)
BackgroundPatients with advanced fibrosis are at risk for developing hepatocellular carcinoma (HCC) even after hepatitis C virus (HCV) elimination. We previously reported that serum fucosylated haptoglobin (Fuc-Hp) levels increase as the disease prog
Externí odkaz:
https://doaj.org/article/0c188d920aa749eb89cf660080d4932f
Autor:
Kumiko Shirai, Hayato Hikita, Sadatsugu Sakane, Ryohei Narumi, Jun Adachi, Akira Doi, Satoshi Tanaka, Yuki Tahata, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Eiji Mita, Takeshi Tomonaga, Tetsuo Takehara
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271020 (2022)
Extracellular vesicles (EVs) contain proteins, mRNAs, and microRNAs, and their cargos have emerged as novel diagnostic markers in various diseases. We aimed to discover novel and noninvasive biomarkers of liver fibrosis by proteomic analysis using se
Externí odkaz:
https://doaj.org/article/1a72e2ccb2194c868b9b999bc039d29a