Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sadasivam Murali"'
Autor:
Simon M. Cool, Tuan Chun Tan, Tingxuan Lin, Sadasivam Murali, Zophia X.H. Lim, Bina Rai, Jaslyn J.L. Lee, Bach Quang Le, Swee Hin Teoh, Victor Nurcombe
Publikováno v:
Journal of Cranio-Maxillofacial Surgery. 47:341-348
Background Cranioplasty is a surgical procedure used to treat a bone defect or deformity in the skull. To date, there is little consensus on the standard-of-care for graft materials used in such a procedure. Graft materials must have sufficient mecha
Autor:
Drew M. Titmarsh, James C.H. Goh, Victor Nurcombe, Sadasivam Murali, Steve Oh, Andre J. van Wijnen, David Robinson, Jason D. Whittle, Gajadhar Bhakta, Lynn Yap, Yu Ming Lim, Robert D. Short, William R. Birch, Muriel Bardor, Lyn Chiin Sim, Allen Chen, Simon M. Cool, Andre Choo
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 106:1887-1896
Functionalizing medical devices with polypeptides to enhance their performance has become important for improved clinical success. The extracellular matrix (ECM) adhesion protein vitronectin (VN) is an effective coating, although the chemistry used t
Autor:
Tracey J. Bell, Ling Ling, James Hoi Po Hui, Sadasivam Murali, Simon M. Cool, Yeong Hui Qing, Sampath Jeewantha Wijesinghe, Victor Nurcombe, Andre J. Van Wijnen, Simon F.R. Hinkley, Kunchithapadam Swaminathan, Susan M. Carnachan
Publikováno v:
Journal of Cellular Physiology. 232:566-575
The future of human mesenchymal stem cells (hMSCs) as a successful cell therapy relies on bioprocessing strategies to improve the scalability of these cells without compromising their therapeutic ability. The culture-expansion of hMSCs can be enhance
Autor:
Sadasivam Murali, Victor Nurcombe, Simon M. Cool, S.A. Fenwick, Tuan Chun Tan, Amber A. Sawyer, A. Chatterjea, Bina Rai, James Hoi Po Hui, Jaslyn J.L. Lee, Zophia X.H. Lim, Yoshinao Z. Hosaka
Publikováno v:
Acta Biomaterialia. 28:193-204
Given the wide spread clinical use of ceramic-based bone void fillers, we sought to determine the efficacy of an FDA-approved β-tricalcium phosphate bone graft substitute (JAX™) in combination with a carboxymethyl cellulose (CMC) handling agent th
Autor:
Simon M. Cool, Bina Rai, Jaslyn J.L. Lee, Victor Nurcombe, Raymond A. A. Smith, Zophia X.H. Lim, Xiaohua Lu, Sadasivam Murali
Publikováno v:
Biomaterials. 184
Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan cl
Autor:
Lynn, Yap, Sadasivam, Murali, Gajadhar, Bhakta, Drew M, Titmarsh, Allen Kuan-Liang, Chen, Lyn, Chiin Sim, Muriel, Bardor, Yu Ming, Lim, James C H, Goh, Steve K W, Oh, Andre B H, Choo, Andre J, van Wijnen, David E, Robinson, Jason D, Whittle, William R, Birch, Robert D, Short, Victor, Nurcombe, Simon M, Cool
Publikováno v:
Journal of biomedical materials research. Part B, Applied biomaterials. 106(5)
Functionalizing medical devices with polypeptides to enhance their performance has become important for improved clinical success. The extracellular matrix (ECM) adhesion protein vitronectin (VN) is an effective coating, although the chemistry used t
Autor:
Saminathan S. Nathan, Bina Rai, James Hoi Po Hui, J.L.J. Lee, Diah S. Bramono, Victor Nurcombe, Hee-Kit Wong, Ling Ling, Sadasivam Murali, Simon M. Cool, Christian Dombrowski, Simon F.R. Hinkley, Zophia X.H. Lim, Tracey J. Bell
Publikováno v:
Biomaterials. 34:5594-5605
Bone morphogenetic protein (BMP)-2 is a potent bone healing compound produced at sites of bone trauma. Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2 by delivery of an affinity-matched heparan sulfate (H
Autor:
Sampath Jeewantha, Wijesinghe, Ling, Ling, Sadasivam, Murali, Yeong Hui, Qing, Simon F R, Hinkley, Susan M, Carnachan, Tracey J, Bell, Kunchithapadam, Swaminathan, James H, Hui, Andre J, van Wijnen, Victor, Nurcombe, Simon M, Cool
Publikováno v:
Journal of cellular physiology. 232(3)
The future of human mesenchymal stem cells (hMSCs) as a successful cell therapy relies on bioprocessing strategies to improve the scalability of these cells without compromising their therapeutic ability. The culture-expansion of hMSCs can be enhance
Autor:
Ling Ling, Sadasivam Murali, Gary S. Stein, Bina Rai, Andre J. van Wijnen, Diah S. Bramono, Wei Theng Poh, Zophia X.H. Lim, Victor Nurcombe, Simon M. Cool
Publikováno v:
Bone. 50:954-964
Lowering the efficacious dose of bone morphogenetic protein-2 (BMP-2) for the repair of critical-sized bone defects is highly desirable, as supra-physiological amounts of BMP-2 have an increased risk of side effects and a greater economic burden for
Publikováno v:
Journal of Biological Chemistry. 286:17755-17765
We compare here the structural and functional properties of heparan sulfate (HS) chains from both male or female adult mouse liver through a combination of molecular sieving, enzymatic cleavage, and strong anion exchange-HPLC. The results demonstrate