Výsledky vyhledávání - "Sadao Matsuura"

Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry

Autor: Toshimitsu Niwa, Naohito Takeda, Hideo Yoshizumi, Toshiharu Nagatsu, Akira Tatematsu, Sadao Matsuura

Publikováno v: Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases ISBN: 9781468458466

After 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was discovered to cause parkinsonism in humans, monkeys, and mice,1–2 Nagatsu et al. screened various compounds structurally similar to MPTP for neurotoxicity by assaying the inhibition of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24a7d50a958eaf4f985ae2d853fe728d
https://doi.org/10.1007/978-1-4684-5844-2_63

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Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline Through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain

Autor: Makoto Naoi, Sadao Matsuura, Tsutomu Takahashi, Toshiharu Nagatsu

Publikováno v: Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases ISBN: 9781468458466

The discovery of N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) as a neurotoxin that elicits symptoms very similar to those of parkinsonism in humans’ indicates that similar compounds may accumulate in human brain and cause neurodegeneration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87dd64e4405fed72efe673a781674120
https://doi.org/10.1007/978-1-4684-5844-2_64

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A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin

Autor: Toshio Horikoshi, Sadao Matsuura, Makoto Sawada, Takashi Sugimoto, Toshiharu Nagatsu, Masahiro Masada, Miki Akino

Publikováno v: Analytical Biochemistry. 154:361-366

A highly sensitive and simple assay for the activity of GTP cyclohydrolase I (EC 3.5.4.16) was established using a newly developed radioimmunoassay. D-erythro-7,8-Dihydroneopterin triphosphate formed from GTP by GTP cyclohydrolase I was oxidized by i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cfa26e805dd1a1a123e3d666efffb5
https://doi.org/10.1016/0003-2697(86)90537-3

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Quinonoid dihydrobiopterin, an important metabolic intermediate of biopterin cofactor in the aromatic hydroxylation of amino acids

Autor: Shizuaki Murata, Sadao Matsuura, Takashi Sugimoto

Publikováno v: Tetrahedron Letters. 27:585-588

p -Quinonoid (6 R )-dihydrobiopterin hydrochloride was synthesized from (6 R )-5,6,7,8-tetrahtdrobiopterin dihydrochloride by hydrogenperoxide in the presence of potassium iodide. Several characters of quinonoid dihydrobiopterin were examined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ad7dce96a91315f4fcf84f824b1093
https://doi.org/10.1016/s0040-4039(00)84047-2

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Imidazopteridines. I. Synthesis of Imidazo[1,2-c]pteridine and Its Alkyl Derivatives

Autor: Sadao Matsuura, Keiko Shibata, Takashi Sugimoto

Publikováno v: Bulletin of the Chemical Society of Japan. 50:2744-2747

The synthesis of imidazo[1,2-c]pteridine and its alkyl derivatives is described. The reaction of 4-aminopteridine with chloroacetaldehyde gave the ring-opened 2-formamido-3-(2-imidazolyl)pyrazine and the isomeric 2-amino-3-(1-formyl-2-imidazolyl)pyra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::656a2896febbb9368331feacee065c3a
https://doi.org/10.1246/bcsj.50.2744

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