Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Sadamu Homma"'
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188934 (2017)
Adjuvants are indispensable for achieving a sufficient immune response from vaccinations. From a functional viewpoint, adjuvants are classified into two categories: "physical adjuvants" increase the efficacy of antigen presentation by antigen-present
Externí odkaz:
https://doaj.org/article/658b5b32738a40148efa91d32074c643
Autor:
Tomoyuki Tano, Masato Okamoto, Shin Kan, Takashi Bando, Hiroyuki Goda, Koh-ichi Nakashiro, Shigetaka Shimodaira, Shigeo Koido, Sadamu Homma, Tomonobu Fujita, Mitsunobu Sato, Naomi Yamashita, Hiroyuki Hamakawa, Yutaka Kawakami
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 805-814 (2013)
Eighty-one patients with oral squamous cell carcinoma (OSCC) received oral fluoropyrimidine UFT and radiotherapy (RT) with or without an immunotherapeutic agent OK-432. Both overall survival and progression-free survival of patients who received RT +
Externí odkaz:
https://doaj.org/article/efe684aff10c4d12998e550e56468b38
Autor:
Tomoyuki Tano, Masato Okamoto, Shin Kan, Koh-ichi Nakashiro, Shigetaka Shimodaira, Shigeo Koido, Sadamu Homma, Mitsunobu Sato, Tomonobu Fujita, Yutaka Kawakami, Hiroyuki Hamakawa
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 3, Pp 305-314 (2013)
Antitumor functions of the host immune system are frequently compromised in patients with malignancies. In the current study, we evaluated the relationship between expression ratio of mRNAs for the antiapoptotic protein Bcl-2 and the proapoptotic pro
Externí odkaz:
https://doaj.org/article/6a023611737a4da1bf4a6fa896a0d81b
Autor:
Kazuki Takakura, Yuichiro Shibazaki, Hiroyuki Yoneyama, Masato Fujii, Taishi Hashiguchi, Zensho Ito, Mikio Kajihara, Takeyuki Misawa, Sadamu Homma, Toshifumi Ohkusa, Shigeo Koido
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142981 (2015)
Chondroitin sulfate E (CS-E), a highly sulfated glycosaminoglycan, is known to promote tumor invasion and metastasis. Because the presence of CS-E is detected in both tumor and stromal cells in pancreatic ductal adenocarcinoma (PDAC), multistage invo
Externí odkaz:
https://doaj.org/article/ba5c26a1fa7e47eb9fdc848fc6f18bc2
Autor:
Masaki Ito, Kazumi Hayashi, Eru Adachi, Tamiko Minamisawa, Sadamu Homma, Shigeo Koido, Kiyotaka Shiba
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110425 (2014)
Invocation of cellular immunity by epitopic peptides remains largely dependent on empirically developed protocols, such as interfusion of aluminum salts or emulsification using terpenoids and surfactants. To explore novel vaccine formulation, epitopi
Externí odkaz:
https://doaj.org/article/fc12cedc1d9e4f4fa3c99d4b244e8d04
Autor:
Yohei Fujita, Masato Okamoto, Hiroyuki Goda, Tomoyuki Tano, Koh-ichi Nakashiro, Atsuro Sugita, Tomonobu Fujita, Shigeo Koido, Sadamu Homma, Yutaka Kawakami, Hiroyuki Hamakawa
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e110378 (2014)
PURPOSE:We investigated whether serum interleukin (IL)-8 reflects the tumor microenvironment and has prognostic value in patients with oral squamous cell carcinoma (OSCC). EXPERIMENTAL DESIGN:Fifty OSCC patients who received radical resection of thei
Externí odkaz:
https://doaj.org/article/0a42b66796984c7087cb7743fa06d5dc
Autor:
Shigeo Koido, Sadamu Homma, Masato Okamoto, Yoshihisa Namiki, Kazuki Takakura, Akitaka Takahara, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Mikio Kajihara, Seiji Arihiro, Hiroo Imazu, Hiroshi Arakawa, Shin Kan, Hideo Komita, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59280 (2013)
Induction of antitumor immunity by dendritic cell (DC)-tumor fusion cells (DC/tumor) can be modulated by their activation status. In this study, to address optimal status of DC/tumor to induce efficient antigen-specific cytotoxic T lymphocytes (CTLs)
Externí odkaz:
https://doaj.org/article/f9bca064f86b47ee88a708ebda059b2e
Autor:
Shigeo Koido, Sadamu Homma, Masato Okamoto, Yoshihisa Namiki, Kazuki Takakura, Akitaka Takahara, Shunichi Odahara, Shintaro Tsukinaga, Toyokazu Yukawa, Jimi Mitobe, Hiroshi Matsudaira, Keisuke Nagatsuma, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hiroo Imazu, Hiroshi Arakawa, Shin Kan, Kazumi Hayashi, Hideo Komita, Yuko Kamata, Masaki Ito, Eiichi Hara, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63498 (2013)
The therapeutic efficacy of fusion cell (FC)-based cancer vaccine generated with whole tumor cells and dendritic cells (DCs) requires the improved immunogenicity of both cells. Treatment of whole tumor cells with ethanol resulted in blockade of immun
Externí odkaz:
https://doaj.org/article/52c8cf7b36164d51a25975fae2501569
Autor:
Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Shintaro Tsukinaga, Jimi Mitobe, Shunichi Odahara, Toyokazu Yukawa, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Kenichi Satoh, Masaki Ito, Hideo Komita, Hiroshi Arakawa, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
Clinical and Developmental Immunology, Vol 2011 (2011)
Pancreatic cancer is a highly aggressive and notoriously difficult to treat. As the vast majority of patients are diagnosed at advanced stage of the disease, only a small population is curative by surgical resection. Although gemcitabine-based chemot
Externí odkaz:
https://doaj.org/article/d18530e749e64929869e2ef3873f94f6
Autor:
Shigeo Koido, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri
Publikováno v:
Clinical and Developmental Immunology, Vol 2010 (2010)
The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce
Externí odkaz:
https://doaj.org/article/9bcbc88057804adab53162508cf3d31a