Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sadafumi Suzuki"'
Autor:
Koji Nishihara, Takahiro Shiga, Eri Nakamura, Tomohiko Akiyama, Takashi Sasaki, Sadafumi Suzuki, Minoru S.H. Ko, Norihiro Tada, Hideyuki Okano, Wado Akamatsu
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 305-318 (2019)
Summary: Although pluripotent stem cells can generate various types of differentiated cells, it is unclear why lineage-committed stem/progenitor cells derived from pluripotent stem cells are decelerated and why the differentiation-resistant propensit
Externí odkaz:
https://doaj.org/article/40748e62b3d34c28a682ce70c8b24703
Autor:
Yasuyoshi Tanaka, Takefumi Sone, Norimichi Higurashi, Tetsushi Sakuma, Sadafumi Suzuki, Mitsuru Ishikawa, Takashi Yamamoto, Jun Mitsui, Hitomi Tsuji, Hideyuki Okano, Shinichi Hirose
Publikováno v:
Stem Cell Research, Vol 28, Iss , Pp 100-104 (2018)
Dravet syndrome (DS) is an infantile epileptic encephalopathy mainly caused by de novo mutations in the SCN1A gene encoding the α1 subunit of the voltage-gated sodium channel Nav1.1. As an in vitro model of this disease, we previously generated an i
Externí odkaz:
https://doaj.org/article/b6a2d611a12444fa922b7b645f0a31e2
Autor:
Fumihiko Kisa, Seiji Shiozawa, Keisuke Oda, Sho Yoshimatsu, Mari Nakamura, Ikuko Koya, Kenji Kawai, Sadafumi Suzuki, Hideyuki Okano
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1825-1838 (2017)
Summary: Several groups have reported the existence of a form of pluripotency that resembles that of mouse embryonic stem cells (mESCs), i.e., a naive state, in human pluripotent stem cells; however, the characteristics vary between reports. The nucl
Externí odkaz:
https://doaj.org/article/71fff79f7716474cb46c6fe2ee818560
Autor:
Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-ichiro Seino, Hideyuki Saya, Hideyuki Okano, Kyoko Miura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-sup
Externí odkaz:
https://doaj.org/article/4c96ca7ac9674011acb4f973f6e4f4db
Autor:
Chizuru Iwasawa, Ryota Tamura, Yuki Sugiura, Sadafumi Suzuki, Naoko Kuzumaki, Minoru Narita, Makoto Suematsu, Masaya Nakamura, Kazunari Yoshida, Masahiro Toda, Hideyuki Okano, Hiroyuki Miyoshi
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 810 (2019)
Human induced pluripotent stem cells (iPSCs) hold enormous promise for regenerative medicine. The major safety concern is the tumorigenicity of transplanted cells derived from iPSCs. A potential solution would be to introduce a suicide gene into iPSC
Externí odkaz:
https://doaj.org/article/e5c76e4adc2044f2bbb6d2167c88a54e
Autor:
Yoko Ogawa, Satoru Morikawa, Hideyuki Okano, Yo Mabuchi, Sadafumi Suzuki, Tomonori Yaguchi, Yukio Sato, Shin Mukai, Saori Yaguchi, Takaaki Inaba, Shinichiro Okamoto, Yutaka Kawakami, Kazuo Tsubota, Yumi Matsuzaki, Shigeto Shimmura
Publikováno v:
eLife, Vol 5 (2016)
Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pathogenesis of fibrosis. Rem
Externí odkaz:
https://doaj.org/article/d7bbc2a8fe4945cd8a1720afc70dc93d
Autor:
Kentaro Yoshioka, Akihisa Oda, Chihiro Notsu, Takafumi Ohtsuka, Yasuhiro Kawai, Sadafumi Suzuki, Takuro Nakamura, Yo Mabuchi, Yumi Matsuzaki, Ryo Goitsuka
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136107 (2015)
Prep1, a TALE-family homeodomain transcription factor, has been demonstrated to play a critical role in embryonic hematopoiesis, as its insufficiency caused late embryonic lethality associated with defective hematopoiesis and angiogenesis. In the pre
Externí odkaz:
https://doaj.org/article/bd8ad6e58f3b43919c66dd8c557fa541
Autor:
Reina Ariki, Satoru Morikawa, Yo Mabuchi, Sadafumi Suzuki, Mayuka Nakatake, Kentaro Yoshioka, Shinya Hidano, Hiromitsu Nakauchi, Yumi Matsuzaki, Takuro Nakamura, Ryo Goitsuka
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87646 (2014)
Hematopoietic stem cells in the bone marrow have the capacity to both self-renew and to generate all cells of the hematopoietic system. The balance of these two activities is controlled by hematopoietic stem cell-intrinsic regulatory mechanisms as we
Externí odkaz:
https://doaj.org/article/75ac196d141f4d9cb019c7790a4ea298
Autor:
Kunimichi Niibe, Yoshimi Kawamura, Daisuke Araki, Satoru Morikawa, Kyoko Miura, Sadafumi Suzuki, Shigeto Shimmura, Takehiko Sunabori, Yo Mabuchi, Yasuo Nagai, Taneaki Nakagawa, Hideyuki Okano, Yumi Matsuzaki
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17610 (2011)
Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by the forced expression of defined transcription factors. Although most somatic cells are capable of acquiring pluripotency with minimal gene transduction, the poo
Externí odkaz:
https://doaj.org/article/adced516ed7c4775bb5c9deba49d731e
Autor:
Daisuke Araki, Daisuke Shimojo, Masunori Kajikawa, Seiko Harada, Chihiro Akazawa, Hideyuki Okano, Yoshimi Kawamura, Sadafumi Suzuki, Yo Mabuchi, Takashi Suyama, Yumi Matsuzaki, Jun Kohyama
Publikováno v:
Stem Cells (Dayton, Ohio)
Human mesenchymal stem/stromal cells (hMSCs) have garnered enormous interest as a potential resource for cell‐based therapies. However, the molecular mechanisms regulating senescence in hMSCs remain unclear. To elucidate these mechanisms, we perfor