Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sadaaki Sawamura"'
Publikováno v:
The Journal of Immunology. 178:5209-5216
The potent role of indigenous microbiota in maintaining murine CMV (MCMV)-specific memory T cells, which were measured by multimer staining, was investigated using germfree (GF) mice. When the BALB/c mice bred under specific pathogen-free (SPF) condi
Autor:
Hidezo Mori, Takako Goto, Shio Jujo, Sadaaki Sawamura, Kentarou Yagi, Koji Kimura, Hidekazu Furuya, Shirosaku Koide, Naoto Fukuyama, Johbu Itoh
Publikováno v:
Journal of Clinical Biochemistry and Nutrition. 38:95-102
We investigated the influence of inducible nitric oxide synthase (iNOS) on acute ischemic injury and chronic angiogenesis. In a hindlimb ischemia model, NO produced by endothelial NO synthase (eNOS) reduces ischemic injury and promotes angiogenesis.
Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet
Autor:
Yi Chen, Yasunori Okada, Naoto Fukuyama, Hiroe Nakazawa, Chizuko Tsuji, Tetsuya Mine, Shinkichi Sato, Yoichi Ogushi, Shigenari Hozawa, Sadaaki Sawamura, Ryuzaburo Tanino
Publikováno v:
Biochemical and Biophysical Research Communications. 326:45-51
The role of inducible nitric oxide synthase (iNOS) in the progression of fibrosis during nonalcoholic steatohepatitis remains to be elucidated. This study examined the role of iNOS in the progression of fibrosis during steatohepatitis by comparing iN
Autor:
Akira Okumura, Sadaaki Sawamura, Toshio Mitomi, Tomoo Tajima, Yutaka Tokuda, Mitsuhiro Kubota, Masatoshi Ohta, Sayoshi Ninomiya, Hiroyasu Makuuchi, Soichi Kuge
Publikováno v:
Japanese Journal of Clinical Oncology. 26:207-210
Intolerable malodor emanating from ulcerated tumors as a result of anaerobic infection is a serious problem in the management of advanced and recurrent breast cancer. Metronidazole can control this malodor, but its oral use may cause adverse reaction
Publikováno v:
Nephron. 74:349-355
The plasma levels of phenol, p-cresol, and indican are markedly increased in uremic patients, and cannot be efficiently reduced by hemodialysis. Such uremic toxins, which are produced in the intestine as bacterial putrefactive metabolites, accumulate
Autor:
Kazuo Hashimoto, Atsushi Ozawa, Shogo Sasaki, Shigeru Arimori, Sadaaki Sawamura, Tadami Nagao, Shuji Yonekura, Mitsumoto Komatsuda
Publikováno v:
Journal of the Japanese Association for Infectious Diseases. 64:963-966
The changes of microbial burdens of six patients with leukemia (four patients with acute leukemia; two patients with chronic leukemia) were studied before and after bone marrow transplantation (BMT) under protected isolation. Oral nonabsorbable and t
Autor:
Sadaaki Sawamura, Kazuo Tanaka
Publikováno v:
International immunopharmacology. 6(4)
The therapeutic effect of a traditional Chinese medicine ren-shen-yang-rong-tang (Japanese name: Ninjin'yoeito, NYT) on murine cytomegalovirus (MCMV)-associated pneumonitis was examined. In MCMV-pneumonitis, IFN-gamma-induced nitric oxide (NO) mediat
Autor:
Yasuyuki Maeda, Noboru Kawabe, Satoshi Noda, Yasuhiro Koga, Hiroki Ishikawa, Yuji Aiba, Hideaki Hasegawa, Kazuo Tanaka, Masayuki Miyasaka, Sadaaki Sawamura
Publikováno v:
Immunobiology. 204(4)
Although intestinal bacterial flora has been thought to play a role in the induction of oral tolerance, the mechanism has yet to be elucidated. We therefore examined the bacterial flora-dependent acquisition of susceptibility to oral tolerance induct
Publikováno v:
Archives of virology. 146(8)
At 4 weeks after intraperitoneal (i.p.) injection of 0.2LD50 (50% lethal dose) of murine cytomegalovirus (MCMV) in adult BALB/c mice, productive virus and the viral DNA were detected only in the salivary glands, but not in the lungs. A single i.p. in
Autor:
Hiroe Nakazawa, Xia Yang, Sadaaki Sawamura, Yasuhiro Koga, Kazuo Tanaka, Kiyotaka Hoshiai, Xi-Lin Niu
Publikováno v:
Circulation. 103(8)
Background —Although endothelial nitric oxide synthase (NOS) is antiatherogenic, the role of inducible NOS (iNOS) in the development of atherosclerosis is not established. Methods and Results —We compared the susceptibility of iNOS knockout (iNOS