Výsledky vyhledávání - "Sacnicte Ramirez"

Akademický článek

A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Autor: Sacnicte Ramirez-Rios, Sophie Michallet, Leticia Peris, Caroline Barette, Clotilde Rabat, Yangbo Feng, Marie-Odile Fauvarque, Annie Andrieux, Karin Sadoul, Laurence Lafanechère

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays sin

Externí odkaz: https://doaj.org/article/adc39229977a4d7ebef42931cfe2c180

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Akademický článek

Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro.

Autor: Anna Klaus, Sarah Zorman, Alexandre Berthier, Cécile Polge, Sacnicte Ramirez, Sylvie Michelland, Michel Sève, Didier Vertommen, Mark Rider, Nicolas Lentze, Daniel Auerbach, Uwe Schlattner

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e62497 (2013)

AMP-activated protein kinase (AMPK) is a cellular and whole body energy sensor with manifold functions in regulating energy homeostasis, cell morphology and proliferation in health and disease. Here we apply multiple, complementary in vitro and in vi

Externí odkaz: https://doaj.org/article/ecd29b6cc2694f8993a9151e2c81222c

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Akademický článek

A versatile multidimensional protein purification system with full Internet remote control based on a standard HPLC system

Autor: Uwe Riek, Sacnicte Ramirez, Theo Wallimann, Uwe Schlattner

Publikováno v: BioTechniques, Vol 46, Iss 6S, Pp ix-xii (2009)

The standard Äkta Explorer high-performance liquid chromatography (HPLC) system has limitations for the automation of multidimensional protein purification. Here, we describe simple modifications that allow for automated multidimensional purificatio

Externí odkaz: https://doaj.org/article/fcb8af32ac04467bb7705745571f52d1

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Akademický článek

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VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules

Autor: Sacnicte Ramirez-Rios, Sung Ryul Choi, Chadni Sanyal, Thorsten B. Blum, Christophe Bosc, Fatma Krichen, Eric Denarier, Jean-Marc Soleilhac, Béatrice Blot, Carsten Janke, Virginie Stoppin-Mellet, Maria M. Magiera, Isabelle Arnal, Michel O. Steinmetz, Marie-Jo Moutin

Publikováno v: The Journal of cell biology. 222(2)

The detyrosination/tyrosination cycle of α-tubulin is critical for proper cell functioning. VASH1-SVBP and VASH2-SVBP are ubiquitous enzyme complexes involved in microtubule detyrosination. However, little is known about their mode of action. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4965e10aa01e8f59f70566810218b744
https://pubmed.ncbi.nlm.nih.gov/36512346

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The detyrosination/re-tyrosination cycle of tubulin and its role and dysfunction in neurons and cardiomyocytes

Autor: Chadni Sanyal, Niels Pietsch, Sacnicte Ramirez Rios, Leticia Peris, Lucie Carrier, Marie-Jo Moutin

Publikováno v: Seminars in celldevelopmental biology. 137

Among the variety of post-translational modifications to which microtubules are subjected, the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and characterized by the enzymatic removal and re-addition of a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc244afe735258d9880ac7aacf7db218
https://pubmed.ncbi.nlm.nih.gov/34924330

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Two antagonistic microtubule targeting drugs act synergistically to kill cancer cells

Publikováno v: Cancers
Cancers, MDPI, 2020, 12 (8), pp.2196. ⟨10.3390/cancers12082196⟩
Volume 12
Issue 8
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 2196, p 2196 (2020)

Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing, however, adverse effects. To reduce the effective dose of paclitaxel, we searched for pharmaceutics which could potentiate its therapeutic effect. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc540bf213bb0b725f448afef66533
http://hdl.handle.net/10261/218415

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A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Autor: Caroline Barette, Karin Sadoul, Laurence Lafanechère, Sacnicte Ramirez-Rios, Leticia Peris, Yangbo Feng, Sophie Michallet, Annie Andrieux, Marie-Odile Fauvarque, Clotilde Rabat

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00543⟩
Frontiers in Pharmacology, Frontiers, 2020, 11, ⟨10.3389/fphar.2020.00543⟩
Frontiers in Pharmacology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba8b31c478fc225e061260485883dcd
https://hal.science/hal-03034431

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Déchiffrage du code tubuline

Autor: Laurence Lafanechère, Anne-Sophie Ribba, Karin Sadoul, Sophie Michallet, Clotilde Joubert, Sacnicte Ramirez-Rios, Lauralie Peronne, E.M. Nolte

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2018, 34 (12), pp.1047-1055. ⟨10.1051/medsci/2018295⟩

International audience; Les microtubules sont des fibres du cytosquelette formées par l’assemblage d’hétérodimères d’α- et de β-tubuline. Ils contribuent à l’établissement de la forme des cellules et de leur polarité, ainsi qu’à l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312db347f778f7911b7a75a0904fa561
https://doi.org/10.1051/medsci/2018295

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A TIRF microscopy assay to decode how tau regulates EB's tracking at microtubule ends

Autor: Laurence Serre, Eric Denarier, Isabelle Arnal, Angélique Vinit, Emilie Courriol, Virginie Stoppin-Mellet, Elea Prezel, Anne Fourest-Lieuvin, Sacnicte Ramirez-Rios, Julie Delaroche

Publikováno v: Methods in au cell biology
Methods in au cell biology, 29 (2), pp.154-165, 2018, ⟨10.1016/bs.mcb.2017.06.013⟩

International audience; Tau is a major microtubule-associated protein (MAP) mainly expressed in the brain. Tau binds the lattice of microtubules and favors their elongation and bundling. Recent studies have shown that tau is also a partner of end-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8fd8b66a147c8af580e2e8275d4884
https://hal.archives-ouvertes.fr/hal-02347006

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