Assessing regulatory information in developmental gene regulatory networks

Autor: Eric H. Davidson, Isabelle S. Peter

Publikováno v: Proceedings of the National Academy of Sciences. 114:5862-5869

Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bb2015704620e98123bd0c43c1881e
https://doi.org/10.1073/pnas.1610616114

Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells

Autor: Hugo J. Parker, Brian D. Slaughter, Bony De Kumar, Robb Krumlauf, Jeffrey J. Lange, Jay R. Unruh, Mark E. Parrish, Ariel Paulson

Publikováno v: Proceedings of the National Academy of Sciences. 114:5838-5845

Homeobox a1 ( Hoxa1 ) is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed Hox gene in the mouse embryo. In this study, we used genomic approaches to identify Hoxa1-bound regions during early stages of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae404f33676e8c712a293f6c031610cb
https://doi.org/10.1073/pnas.1610612114

Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

Autor: Ali Mortazavi, Jingli A. Zhang, Camden Jansen, Weihua Zeng, Pentao Liu, Maile Romero-Wolf, Long Li, William J.R. Longabaugh, Hiroyuki Hosokawa, Ellen V. Rothenberg, Hao Yuan Kueh

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(23)

T-cell development from hematopoietic progenitors depends on multiple transcription factors, mobilized and modulated by intrathymic Notch signaling. Key aspects of T-cell specification network architecture have been illuminated through recent reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04767ac71f5646cf1daa5954813f286
https://pubmed.ncbi.nlm.nih.gov/28584128

Causes and evolutionary consequences of primordial germ-cell specification mode in metazoans

Autor: Carrie A. Whittle, Cassandra G. Extavour

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(23)

In animals, primordial germ cells (PGCs) give rise to the germ lines, the cell lineages that produce sperm and eggs. PGCs form in embryogenesis, typically by one of two modes: a likely ancestral mode wherein germ cells are induced during embryogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee7f77c7a2c6c531f6eba3ceebd6ce8
https://pubmed.ncbi.nlm.nih.gov/28584112

Logical modeling of lymphoid and myeloid cell specification and transdifferentiation

Autor: Wassim Abou-Jaoudé, Morgane Thomas-Chollier, Samuel Collombet, Bruno Di Stefano, Jose Luis Sardina Ortega, Thomas Graf, Chris van Oevelen, Denis Thieffry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (23), pp.5792-5799. ⟨10.1073/pnas.1610622114⟩

International audience; Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b293639bed01181c0afe2e929f2909
https://pubmed.ncbi.nlm.nih.gov/28584084