Výsledky vyhledávání - "Sachiyo Miyao"

Akademický článek

A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

Autor: Hiroko Shimada, Yuta Sato, Takashi Sasaki, Aki Shimozawa, Kent Imaizumi, Tomoko Shindo, Sachiyo Miyao, Kosuke Kiyama, Takahiro Kondo, Shinsuke Shibata, Seiji Ishii, Junro Kuromitsu, Hirofumi Aoyagi, Daisuke Ito, Hideyuki Okano

Publikováno v: Cell Reports: Methods, Vol 2, Iss 9, Pp 100289- (2022)

Summary: It is known that the human cellular models of Alzheimer’s disease (AD) and tauopathy can only recapitulate the very early stage of the disease. To overcome these limitations, we developed a technology to make forebrain organoids (FBOs) fro

Externí odkaz: https://doaj.org/article/76cc1ea34301473bb0005b49238851d0

Zobrazit plný text záznamu

The Drosophila Ral GTPase Regulates Developmental Cell Shape Changes through the Jun NH2-terminal Kinase Pathway

Autor: Shinya Koyama, Hideyuki Okano, Per Winge, Yuki Hirota, Sachiyo Miyao, Kazunobu Sawamoto, Ming Hao Jin, Akira Kikuchi, Shingo Yoshikawa, Chiharu Yamada

Publikováno v: The Journal of Cell Biology

The Ral GTPase is activated by RalGDS, which is one of the effector proteins for Ras. Previous studies have suggested that Ral might function to regulate the cytoskeleton; however, its in vivo function is unknown. We have identified a Drosophila homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0696b42bfc257ce1d2508889f8ff66e3
https://doi.org/10.1083/jcb.146.2.361

Zobrazit plný text záznamu

Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets

Autor: Tatsuji Nomura, Masanori Sakaguchi, Sachiyo Miyao, Yoshiaki Toyama, Yonehiro Kanemura, Masayuki Yamada, Norikazu Tamaoki, Hiroyuki Katoh, Ken Ishii, Akio Iwanami, Masaya Nakamura, Junichi Yamane, Suketaka Momoshima, Hirotaka James Okano, Hideyuki Okano

Publikováno v: Journal of Neuroscience Research.

Delayed transplantation of neural stem/progenitor cells (NS/PCs) into the injured spinal cord can promote functional recovery in adult rats and monkeys. To enhance the functional recovery after NS/PC transplantation, we focused on galectin-1, a carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481765444e66804ec40afb280b5be46a
https://doi.org/10.1002/jnr.22322

Zobrazit plný text záznamu

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats

Autor: Masahiko Watanabe, Yasuo Uchiyama, Kazunobu Sawamoto, Masaya Nakamura, Sachiyo Miyao, Masato Koike, Hideyuki Okano, Yuto Ogawa, Takaki Miyata, Barbara S. Bregman, Yoshiaki Toyama

Publikováno v: Journal of neuroscience research. 69(6)

Neural progenitor cells, including neural stem cells, are a potential expandable source of graft material for transplantation aimed at repairing the damaged CNS. Here we present the first evidence that in vitro-expanded fetus-derived neurosphere cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746c30282ce51a1cc054bb5dc575c89a
https://pubmed.ncbi.nlm.nih.gov/12205685

Zobrazit plný text záznamu