Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sachini U. Siriwardena"'
Autor:
Rajaiah Pergu, Veronika M. Shoba, Santosh K. Chaudhary, Dhanushka N. P. Munkanatta Godage, Arghya Deb, Santanu Singha, Uttam Dhawa, Prashant Singh, Viktoriya Anokhina, Sameek Singh, Sachini U. Siriwardena, Amit Choudhary
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1558-1566 (2023)
Externí odkaz:
https://doaj.org/article/5f26eff2f0e94069a68f34dcd47b3735
Autor:
Veronika M. Shoba, Dhanushka N. P. Munkanatta Godage, Santosh K. Chaudhary, Arghya Deb, Sachini U. Siriwardena, Amit Choudhary
Publikováno v:
Angewandte Chemie. 134
Phosphorylation-inducing chimeric small molecules (PHICS) can enable a kinase to act at a new cellular location or phosphorylate non-native substrates (neo-substrates)/ sites (neo-phosphorylations).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42dfc60f2e92ec7f3cc7b72dbad1d370
https://doi.org/10.1002/ange.202202770
https://doi.org/10.1002/ange.202202770
Autor:
Linda Chelico, Seongho Kim, Kayla L. Conner, Ashley M. Floyd, Michele L. Cote, Wen Lei, Jacob Lindquist, Steve M. Patrick, Akshada Sawant, Ashok S. Bhagwat, Asra N. Shaik, Madison B. Adolph, Sachini U. Siriwardena, Katie A Marshall, Elmira Ekinci
Publikováno v:
Nar Cancer
Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f68c914ae47b3521bbcc03538c65f37
https://doi.org/10.1093/narcan/zcaa033
https://doi.org/10.1093/narcan/zcaa033
Autor:
Stuart L. Schreiber, Veronika Shoba, Peng Wu, Sachini U. Siriwardena, Mengchao Shi, Sophia Lai, Dhanushka N P Munkanatta Godage, Santosh K. Chaudhary, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society. 142(33)
Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect are emerging. Phosphorylation (native or neo) of any given protein-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6b4909767e75e16a6ba971ae291a5b
https://pubmed.ncbi.nlm.nih.gov/32787262
https://pubmed.ncbi.nlm.nih.gov/32787262
Publikováno v:
Nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0e095548f078d9d5dcb1aa4adbad80
https://pubmed.ncbi.nlm.nih.gov/23242138
https://pubmed.ncbi.nlm.nih.gov/23242138
Publikováno v:
Chemical Reviews. 116:12688-12710
The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines produced during the body’s inflammatory response to infections, and they help combat infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2e6f1d56910aec81523bf484020cb7
https://doi.org/10.1021/acs.chemrev.6b00296
https://doi.org/10.1021/acs.chemrev.6b00296
Autor:
Sachini U. Siriwardena, Ashok S. Bhagwat, Madusha L. W. Perera, Jessica A. Stewart, Vimukthi Senevirathne
Publikováno v:
Molecular and cellular biology. 39(1)
Phorbol 12-myristate 13-acetate (PMA) promotes skin cancer in rodents. The mutations found in murine tumors are similar to those found in human skin cancers, and PMA promotes proliferation of human skin cells. PMA treatment of human keratinocytes inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8848fe755191ff0cb9d7dd20e028b65
https://pubmed.ncbi.nlm.nih.gov/30348839
https://pubmed.ncbi.nlm.nih.gov/30348839
Autor:
Beverly Mok, Donghyun Lim, Bishwajit Paul, Soumyashree A. Gangopadhyay, Amedeo Vetere, Bridget K. Wagner, Amit Choudhary, Paul A. Clemons, Vlado Dančík, Luciano A. Marraffini, Peng Wu, Robert Heler, Sachini U. Siriwardena, David R. Liu, Miseon Lee, Michael F. Mesleh, Basudeb Maji, Mengchao Shi
Publikováno v:
Cell. 177:1067-1079.e19
The precise control of CRISPR-Cas9 activity is required for a number of genome engineering technologies. Here, we report a generalizable platform that provided the first synthetic small-molecule inhibitors of Streptococcus pyogenes Cas9 (SpCas9) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c99eaf7b1001b79f1f38ef5021f0621
https://doi.org/10.1016/j.cell.2019.04.009
https://doi.org/10.1016/j.cell.2019.04.009
Human APOBEC3B deaminates cytosines in DNA and belongs to the AID/APOBEC family of enzymes. These proteins are involved in innate and adaptive immunity and may cause mutations in a variety of cancers. To characterize its ability to convert cytosines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaefa111ab1acea501726025d3f0820
https://europepmc.org/articles/PMC4579057/
https://europepmc.org/articles/PMC4579057/
